Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats
文献类型：期刊论文
| 作者 | Wang, Lijuan; Wang, Lin; Ding, Wenjun; Zhang, Fang |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 10期号:12页码:8617-8624 |
| 关键词 | Acute toxicity Nanoscale fe2o3 Nanoscale zno Rats |
| ISSN号 | 1533-4880 |
| DOI | 10.1166/jnn.2010.2483 |
| 通讯作者 | Ding, wenjun() |
| 英文摘要 | We investigated the toxic effects of inhalation exposure to ferric oxide (fe2o3) and zinc oxide (zno) nanoparticles in rats. male wistar rats were consecutively treated with fe2o3 at 8.5 mg/kg body weight and zno nanoparticles at 2.5 mg/kg body weight, twice daily for 3 days. content of fe2o3 and zno in tissues, biochemical parameters in serum, and hispathological examinations were analyzed at 12 h and 36 h after the 3 day treatment. in the fe2o3-treated group, iron (fe) content in liver and lung tissues was significantly increased at 36 h. in the zno-treated group, zinc (zn) content in liver tissues was significantly increased at 12 h and further increased at 36 h. the levels of serum alanine aminotransferase (alt), aspartate aminotransferase (ast), alkaline phosphatase (alp), total protein (tp), creatine kinase (ck), and lactate dehydrogenase (ldh) in both nanoparticle-exposed groups were significantly decreased compared to the unexposed controls. histopathological examination showed that both types of nanoparticles caused severe damage in liver and lung tissues. although this damage progressed in both liver and lung throughout the post-exposure period, no significant elevation of serum enzyme activities was observed in response to either nanoparticle type. |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| WOS记录号 | WOS:000283621400101 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412883 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ding, Wenjun |
| 作者单位 | Chinese Acad Sci, Grad Univ, Coll Life Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Lijuan,Wang, Lin,Ding, Wenjun,et al. Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats[J]. Journal of nanoscience and nanotechnology,2010,10(12):8617-8624. |
| APA | Wang, Lijuan,Wang, Lin,Ding, Wenjun,&Zhang, Fang.(2010).Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats.Journal of nanoscience and nanotechnology,10(12),8617-8624. |
| MLA | Wang, Lijuan,et al."Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats".Journal of nanoscience and nanotechnology 10.12(2010):8617-8624. |
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来源：中国科学院大学
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