Application of "click chemistry" in synthesis of radiopharmaceuticals
文献类型：期刊论文
| 作者 | Wang Cheng1,2; Wang Ni1; Zhou Wei1; Shen Yumei1; Zhang Lan1 |
| 刊名 | Progress in chemistry
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 22期号:8页码:1591-1602 |
| ISSN号 | 1005-281X |
| 关键词 | Click chemistry Radiopharmaceuticals Labelled compounds Pet imaging Spet imaging |
| 通讯作者 | Zhou wei(zhouwei@sinap.ac.cn) |
| 英文摘要 | "click chemistry" is a new synthetic method which has being developed in recent years. due to its numerous advantages, its applications have been paid close attentions and developed rapidly including the synthesis of lead compound database, proteome, bioconjugate technology and biomedicine. recently, click chemistry, and in particular the cu(+)-mediated 1, 3-dipolar [3 + 2] cycloaddition between azides and alkynes, has also entered the field of radiopharmaceutical science. in this paper, the conception, characteristics and reaction mechanisms of "click chemistry" are reviewed. particularly, the recent developments of click chemistry applied in synthesizing various radiotracers, radiopharmaceuticals, labelled compounds and pet imaging are addressed. the radionuclides include (18)f and (11)c used for pet imaging and (99m)tc, (188)re, (125)i, (111)in for spect imaging. the prospects of this application in radiopharmaceutical science are analyzed. |
| WOS关键词 | AZIDE-ALKYNE CYCLOADDITION ; POSITRON-EMISSION-TOMOGRAPHY ; 1,3-DIPOLAR CYCLOADDITION ; TERMINAL ALKYNES ; IN-SITU ; COPPER NANOPARTICLES ; HETEROGENEOUS CATALYST ; PRECLINICAL EVALUATION ; BIFUNCTIONAL LIGAND ; EFFICIENT SYNTHESIS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | CHINESE ACAD SCIENCES |
| WOS记录号 | WOS:000281270600010 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2412902 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Radiopharmaceut Ctr, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang Cheng,Wang Ni,Zhou Wei,et al. Application of "click chemistry" in synthesis of radiopharmaceuticals[J]. Progress in chemistry,2010,22(8):1591-1602. |
| APA | Wang Cheng,Wang Ni,Zhou Wei,Shen Yumei,&Zhang Lan.(2010).Application of "click chemistry" in synthesis of radiopharmaceuticals.Progress in chemistry,22(8),1591-1602. |
| MLA | Wang Cheng,et al."Application of "click chemistry" in synthesis of radiopharmaceuticals".Progress in chemistry 22.8(2010):1591-1602. |
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来源：中国科学院大学
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