Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression
文献类型：期刊论文
| 作者 | Han, Yanjiang1,2; Yin, Duanzhi1; Zheng, Mingqiang1; Zhou, Wei1; Lee, ZhenHong; Zhan, Lan1; Ma, Yufei1; Wu, Mingxing1; Shi, Lingli1; Wang, Ni1 |
| 刊名 | Journal of radioanalytical and nuclear chemistry
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 284期号:2页码:279-286 |
| 关键词 | Cxcr4 Sdf-1 Sib Radioiodination |
| ISSN号 | 0236-5731 |
| DOI | 10.1007/s10967-010-0484-x |
| 通讯作者 | Wang, yongxian(yongxianw@163.com) |
| 英文摘要 | The aim of this study was to develop a radiopharmaceutical for the imaging of cxcr4-expressing tumors in vivo. for i-125-labeling, i-125-sib was synthesized and conjugated with the epsilon-nh2 group of ac-tz14011, a specific cxcr4 antagonist. the specific radioactivity of the product was 5 gbq/mu mol and the radiochemical purity (rcp) was 96% (n = 3). after 6 h, the rcp of the product in pbs was 93%. the mcf-7 cell uptake of ac-tz14011 was rapid and high. primary biodistribution studies indicated that i-125-ib-ac-tz14011 was mainly excreted via the kidney, and further evaluation in mice with induced tumors was necessary. |
| WOS关键词 | GROWTH-STIMULATING FACTOR ; BREAST-CANCER METASTASIS ; N-SUCCINIMIDYL ; CHEMOKINE RECEPTORS ; MOLECULAR-CLONING ; PERIPHERAL-BLOOD ; CELLS ; ENTRY ; SDF-1 ; BONE |
| WOS研究方向 | Chemistry ; Nuclear Science & Technology |
| WOS类目 | Chemistry, Analytical ; Chemistry, Inorganic & Nuclear ; Nuclear Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000276910000004 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413122 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Yongxian |
| 作者单位 | 1.Chinese Acad Sci, Res Ctr Radiopharmaceut, Shanghai Inst Appl Phys, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Case Western Reserve Univ, Dept Nucl Med Radiol, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA |
| 推荐引用方式 GB/T 7714 | Han, Yanjiang,Yin, Duanzhi,Zheng, Mingqiang,et al. Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression[J]. Journal of radioanalytical and nuclear chemistry,2010,284(2):279-286. |
| APA | Han, Yanjiang.,Yin, Duanzhi.,Zheng, Mingqiang.,Zhou, Wei.,Lee, ZhenHong.,...&Wang, Yongxian.(2010).Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression.Journal of radioanalytical and nuclear chemistry,284(2),279-286. |
| MLA | Han, Yanjiang,et al."Synthesis and preliminary evaluation of a novel i-125-labeled t140 analog for quantitation of cxcr4 expression".Journal of radioanalytical and nuclear chemistry 284.2(2010):279-286. |
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来源：中国科学院大学
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