Viable fertile mice generated from fully pluripotent ips cells derived from adult somatic cells
文献类型：期刊论文
| 作者 | Zhao, Xiao-yang1,4; Li, Wei1,4; Lv, Zhuo1,4; Liu, Lei1; Tong, Man1,4; Hai, Tang1; Hao, Jie1,4; Wang, Xiang2; Wang, Liu1; Zeng, Fanyi2,3 |
| 刊名 | Stem cell reviews and reports
 |
| 出版日期 | 2010-09-01 |
| 卷号 | 6期号:3页码:390-397 |
| 关键词 | Ips cells Tail tip fibroblast (ttf) Fully pluripotent Tetraploid complementation Viable mice |
| ISSN号 | 1550-8943 |
| DOI | 10.1007/s12015-010-9160-3 |
| 通讯作者 | Zhou, qi(qzhou@ioz.ac.cn) |
| 英文摘要 | Previous studies demonstrated that induced pluripotent stem (ips) cells could produce viable mice through tetraploid complementation, which was thought to be the most stringent test for pluripotency. however, these highly pluripotent ips cells were previously reported to be generated from fibroblasts of embryonic origin. achieving fully pluripotent ips cells from multiple cell types, especially easily accessible adult tissues, will lead to a much greater clinical impact. we successfully generated high-pluripotency ips cells from adult tail tip fibroblasts (ttf) that resulted in viable, full-term, fertile ttf-ips animals with no obvious teratoma formation or other developmental abnormalities. comparison of ips cells from embryonic origin (mef), progenitor cells (neural stem cells) or differentiated somatic cells (ttf) reveals that fully pluripotent developmental potential can be reached by each cell type, although with different induction efficiencies. this work provides the means for studying the mechanisms and regulation of direct reprogramming, and has encouraging implications for future clinical applications and therapeutic interventions. |
| WOS关键词 | EMBRYONIC STEM-CELLS ; NUCLEAR TRANSFER ; MOUSE ; FIBROBLASTS ; STATE |
| WOS研究方向 | Cell Biology ; Research & Experimental Medicine |
| WOS类目 | Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000281649900007 |
| 出版者 | SPRINGER HEIDELBERG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413215 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Qi |
| 作者单位 | 1.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China 2.Shanghai Jiao Tong Univ, Childrens Hosp, Shanghai Inst Med Genet, Shanghai 200030, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Inst Med Sci, Shanghai 200030, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Xiao-yang,Li, Wei,Lv, Zhuo,et al. Viable fertile mice generated from fully pluripotent ips cells derived from adult somatic cells[J]. Stem cell reviews and reports,2010,6(3):390-397. |
| APA | Zhao, Xiao-yang.,Li, Wei.,Lv, Zhuo.,Liu, Lei.,Tong, Man.,...&Zhou, Qi.(2010).Viable fertile mice generated from fully pluripotent ips cells derived from adult somatic cells.Stem cell reviews and reports,6(3),390-397. |
| MLA | Zhao, Xiao-yang,et al."Viable fertile mice generated from fully pluripotent ips cells derived from adult somatic cells".Stem cell reviews and reports 6.3(2010):390-397. |
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来源：中国科学院大学
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