Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3t3-l1 adipocytes
文献类型：期刊论文
| 作者 | Hao, Jiejie2,3; Shen, Weili2; Yu, Guangli4; Jia, Haiqun2,3; Li, Xuesen2,3; Feng, Zhihui2,3; Wang, Ying5; Weber, Peter5; Wertz, Karin5; Sharman, Edward6 |
| 刊名 | Journal of nutritional biochemistry
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 21期号:7页码:634-644 |
| 关键词 | 5 ' amp-activated protein kinase (ampk) Fatty acid oxidation Mitochondrial transcription factor a (tfam) Mitochondrial dna (mtdna) Nuclear respiration factors 1 and 2 (nrf1 and nrf2) Peroxisome proliferator-activated receptor coactivator 1 alpha (ppargc1 alpha) |
| ISSN号 | 0955-2863 |
| DOI | 10.1016/j.jnutbio.2009.03.012 |
| 通讯作者 | Liu, jiankang(j.liu@mail.xjtu.edu.cn) |
| 英文摘要 | Hydroxytyrosol (ht) in extra-virgin olive oil is considered one of the most important polyphenolic compounds responsible for the health benefits of the mediterranean diet for lowering incidence of cardiovascular disease, the most common and most serious complication of diabetes. we propose that ht may prevent these diseases by a stimulation of mitochondrial biogenesis that leads to enhancement of mitochondrial function and cellular defense systems. in the present study, we investigated effects of ht that stimulate mitochondrial biogenesis and promote mitochondrial function in 3t3-l1 adipocytes. ht over the concentration range of 0.1-10 mu mol/l stimulated the promoter transcriptional activation and protein expression of peroxisome proliferator-activated receptor (ppar) coactivator 1 alpha (ppargc1 alpha, the central factor for mitochondrial biogenesis) and its downstream targets; these included nuclear respiration factors 1 and 2 and mitochondrial transcription factor a, which leads to an increase in mitochondrial dna (mtdna) and in the number of mitochondria. knockdown of ppargc1 alpha by sirna blocked ht's stimulating effect on complex i expression and mtdna copy number. the ht treatment resulted in an enhancement of mitochondrial function, including an increase in activity and protein expression of mitochondrial complexes i, ii, iii and v; increased oxygen consumption; and a decrease in free fatty acid contents in the adipocytes. the mechanistic study of the ppargc1 alpha activation signaling pathway demonstrated that ht is an activator of 5'amp-activated protein kinase and also up-regulates gene expression of ppar alpha, cpt-1 and ppar gamma. these data suggest that ht is able to promote mitochondrial function by stimulating mitochondrial biogenesis. (c) 2010 elsevier inc. all rights reserved. |
| WOS关键词 | ACTIVATED PROTEIN-KINASE ; ACETYL-COA CARBOXYLASE ; ALPHA-LIPOIC ACID ; INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; OLIVE OIL ; OXIDATIVE-PHOSPHORYLATION ; CARDIOVASCULAR-DISEASE ; COGNITIVE DYSFUNCTION ; ANTIOXIDANT ACTIVITY |
| WOS研究方向 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| WOS类目 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000279363200010 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413253 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Liu, Jiankang |
| 作者单位 | 1.Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn,Dept Biol & Engn,Ins, Xian 710049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 4.Ocean Univ China, Sch Med & Pharm, Qingdao, Peoples R China 5.R&D Human Nutr & Hlth, DSM Nutr Prod, Basel, Switzerland 6.Univ Calif Irvine, Dept Neurol, Irvine, CA 92697 USA |
| 推荐引用方式 GB/T 7714 | Hao, Jiejie,Shen, Weili,Yu, Guangli,et al. Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3t3-l1 adipocytes[J]. Journal of nutritional biochemistry,2010,21(7):634-644. |
| APA | Hao, Jiejie.,Shen, Weili.,Yu, Guangli.,Jia, Haiqun.,Li, Xuesen.,...&Liu, Jiankang.(2010).Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3t3-l1 adipocytes.Journal of nutritional biochemistry,21(7),634-644. |
| MLA | Hao, Jiejie,et al."Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3t3-l1 adipocytes".Journal of nutritional biochemistry 21.7(2010):634-644. |
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来源：中国科学院大学
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