Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells
文献类型：期刊论文
| 作者 | Liu, Xin1,4; Ou, Yingyong1,2; Chen, Shaopeng1; Lu, Xin1; Cheng, Hao1; Jia, Xian2; Wang, Decai3; Zhou, Guo-Chun1,4 |
| 刊名 | European journal of medicinal chemistry
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 45期号:6页码:2147-2153 |
| 关键词 | Alkylation Cyclohexen-2-yl-substituted phenol Cyclohexen-2-yl-substituted quinone Cell proliferation |
| ISSN号 | 0223-5234 |
| DOI | 10.1016/j.ejmech.2010.01.051 |
| 通讯作者 | Zhou, guo-chun() |
| 英文摘要 | Alkylanon of phenols with 1,3-cyclohexadiene (1) has been conducted and a series of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones were screened against the proliferation of huvec and cancer cells. phenol type as well as the size and occupied position of the substitute are important for the alkylating reaction and the inhibitory activity and selectivity of a compound. 2,5-di(cyclohexen-2-yl)benzene-1,4-diol (25) bearing two cyclohexen-2-yl groups and 2-tert-butyl-5-(cyclohexen-2-yl)benzene-1,4-diol (30) bearing cyclohexen-2-yl and tert-butyl groups exhibited good selectivity against huvec pioliferation (ic(50)s of 2 0 and 1 4 mu m, respectively) with relatively low toxicity to ccc-hpf-1. |
| WOS关键词 | ALLYL ARYL ETHERS ; ANGIOGENESIS ; REARRANGEMENT ; CYCLOALKENEDIOLS ; HYDROQUINONE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000278056000005 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413541 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Guo-Chun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China 3.Nanjing Univ Technol, Sch Pharmaceut Sci, Nanjing 210000, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xin,Ou, Yingyong,Chen, Shaopeng,et al. Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells[J]. European journal of medicinal chemistry,2010,45(6):2147-2153. |
| APA | Liu, Xin.,Ou, Yingyong.,Chen, Shaopeng.,Lu, Xin.,Cheng, Hao.,...&Zhou, Guo-Chun.(2010).Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells.European journal of medicinal chemistry,45(6),2147-2153. |
| MLA | Liu, Xin,et al."Synthesis and inhibitory evaluation of cyclohexen-2-yl- and cyclohexyl-substituted phenols and quinones to endothelial cell and cancer cells".European journal of medicinal chemistry 45.6(2010):2147-2153. |
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来源：中国科学院大学
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