Radiosynthesis and micro-spect imaging of tc-99m-dendrimer poly(amido)-amine folic acid conjugate
文献类型：期刊论文
| 作者 | Zhang, Yuanqing1,2; Sun, Yanhong1; Xu, Xiaoping1,2; Zhu, Hua1,2; Huang, Liliang1,2; Zhang, Xuezhu1,2; Qi, Yujin1; Shen, Yu-Mei1,3 |
| 刊名 | Bioorganic & medicinal chemistry letters
 |
| 出版日期 | 2010-02-01 |
| 卷号 | 20期号:3页码:927-931 |
| 关键词 | Dendrimer pamam Radiolabeling Folate receptor Micro-spect imaging |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2009.12.075 |
| 通讯作者 | Shen, yu-mei(shenyumei@sinap.ac.cn) |
| 英文摘要 | Acetylated (ac) dendrimer poly(amido)-amine (pamam) generation 5 (g5) reacted with folic acid (fa), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1b4m dtpa) to form the conjugate of ac-g5-fa-1b4m dtpa which was further radiolabeled with tc-99m. the radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-spect imaging study. (c) 2009 elsevier ltd. all rights reserved. |
| WOS关键词 | MULTIFUNCTIONAL NANODEVICES ; DENDRITIC MACROMOLECULES ; BIOMEDICAL APPLICATIONS ; INFLAMMATORY DISEASES ; STARBURST DENDRIMERS ; MONOCLONAL-ANTIBODY ; FOLATE RECEPTOR ; DRUG-DELIVERY ; CANCER ; THERAPY |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000273783800027 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413562 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shen, Yu-Mei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Shanghai Jiao Tong Univ, Shanghai Ctr Syst Biomed, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yuanqing,Sun, Yanhong,Xu, Xiaoping,et al. Radiosynthesis and micro-spect imaging of tc-99m-dendrimer poly(amido)-amine folic acid conjugate[J]. Bioorganic & medicinal chemistry letters,2010,20(3):927-931. |
| APA | Zhang, Yuanqing.,Sun, Yanhong.,Xu, Xiaoping.,Zhu, Hua.,Huang, Liliang.,...&Shen, Yu-Mei.(2010).Radiosynthesis and micro-spect imaging of tc-99m-dendrimer poly(amido)-amine folic acid conjugate.Bioorganic & medicinal chemistry letters,20(3),927-931. |
| MLA | Zhang, Yuanqing,et al."Radiosynthesis and micro-spect imaging of tc-99m-dendrimer poly(amido)-amine folic acid conjugate".Bioorganic & medicinal chemistry letters 20.3(2010):927-931. |
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来源：中国科学院大学
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