Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks
文献类型：期刊论文
| 作者 | Chang, Xiao1,2,3; Wang, Zhuo4; Hao, Pei1,2; Li, Yuan-Yuan1,2; Li, Yi-Xue1,2 |
| 刊名 | Genomics
 |
| 出版日期 | 2010-06-01 |
| 卷号 | 95期号:6页码:339-344 |
| 关键词 | Metabolic network Betweenness centrality Degree centrality Triad significance profiles |
| ISSN号 | 0888-7543 |
| DOI | 10.1016/j.ygeno.2010.03.006 |
| 通讯作者 | Li, yuan-yuan(yyli@scbit.org) |
| 英文摘要 | The endosymbiotic theory proposed that mitochondrial genomes are derived from an alpha-proteobacterium-like endosymbiont, which was concluded from sequence analysis. we rebuilt the metabolic networks of mitochondria and 22 relative species, and studied the evolution of mitochondrial metabolism at the level of enzyme content and network topology. our phylogenetic results based on network alignment and motif identification supported the endosymbiotic theory from the point of view of systems biology for the first time. it was found that the mitochondrial metabolic network were much more compact than the relative species, probably related to the higher efficiency of oxidative phosphorylation of the specialized organelle, and the network is highly clustered around the tca cycle. moreover, the mitochondrial metabolic network exhibited high functional specificity to the modules. this work provided insight to the understanding of mitochondria evolution, and the organization principle of mitochondrial metabolic network at the network level. (c) 2010 elsevier inc. all rights reserved. |
| WOS关键词 | SYSTEMS BIOLOGY ; COMPLEX NETWORKS ; GENOME-SCALE ; RECONSTRUCTION ; ORIGIN ; ORGANISMS ; BACTERIA ; MOTIFS ; PROTEOME ; ENZYMES |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| WOS类目 | Biotechnology & Applied Microbiology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000278341600003 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413586 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, Yuan-Yuan |
| 作者单位 | 1.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Bioinformat Ctr, Key Lab Syst Biol, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 4.Shanghai Jiao Tong Univ, Coll Life Sci & Biotechnol, Shanghai 200240, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chang, Xiao,Wang, Zhuo,Hao, Pei,et al. Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks[J]. Genomics,2010,95(6):339-344. |
| APA | Chang, Xiao,Wang, Zhuo,Hao, Pei,Li, Yuan-Yuan,&Li, Yi-Xue.(2010).Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks.Genomics,95(6),339-344. |
| MLA | Chang, Xiao,et al."Exploring mitochondrial evolution and metabolism organization principles by comparative analysis of metabolic networks".Genomics 95.6(2010):339-344. |
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来源：中国科学院大学
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