Heterodimers of histidine and amantadine as inhibitors for wild type and mutant m2 channels of influenza a
文献类型：期刊论文
| 作者 | Zhang Wenjuan1,2; Xu Jing1; Liu Fang1,3; Li Chufang1; Jie Yanling1; Chen Shaopeng1; Li Zhiyuan1; Liu Jinsong1; Chen Ling1; Zhou Guochun1,2 |
| 刊名 | Chinese journal of chemistry
 |
| 出版日期 | 2010-08-01 |
| 卷号 | 28期号:8页码:1417-1423 |
| 关键词 | M2 ion channel Imidazole Histidine Amantadine Inhibitor Amination |
| ISSN号 | 1001-604X |
| 通讯作者 | Zhou guochun(springzhou@yahoo.com) |
| 英文摘要 | Inhibitors bearing the imidazole, adamantane and related structures were synthesized and tested against wt, s31n and s31n-l261 mutant m2 channels. although amantadine (1) only inhibited wt m2 channel, compound 6 containing the imidazole and adamantane groups showed good inhibitory activity to wt and mutant m2 channels. the stereochemistry and basic pk(a) of alpha-amine are important for the activity of inhibitors and our data showed that derivatives of natural histidine are more active for m2 channels than those of unnatural histidine. the significance of our present results is that we have established a prospective strategy of drug discovery of wt and mutant m2 channels against influenza a. |
| WOS关键词 | TRANSMEMBRANE PROTON CHANNEL ; VIRUSES ISOLATED WORLDWIDE ; ION-CHANNEL ; ADAMANTANE RESISTANCE ; SELECTIVITY ; RIMANTADINE ; EMERGENCE ; A(H3N2) ; CELLS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000281546600017 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413668 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou Guochun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510663, Guangdong, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang Wenjuan,Xu Jing,Liu Fang,et al. Heterodimers of histidine and amantadine as inhibitors for wild type and mutant m2 channels of influenza a[J]. Chinese journal of chemistry,2010,28(8):1417-1423. |
| APA | Zhang Wenjuan.,Xu Jing.,Liu Fang.,Li Chufang.,Jie Yanling.,...&Zhou Guochun.(2010).Heterodimers of histidine and amantadine as inhibitors for wild type and mutant m2 channels of influenza a.Chinese journal of chemistry,28(8),1417-1423. |
| MLA | Zhang Wenjuan,et al."Heterodimers of histidine and amantadine as inhibitors for wild type and mutant m2 channels of influenza a".Chinese journal of chemistry 28.8(2010):1417-1423. |
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来源：中国科学院大学
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