Regulation of fasting fuel metabolism by toll-like receptor 4
文献类型：期刊论文
| 作者 | Pang, Shanshan; Tang, Haiqing; Zhuo, Shu; Zang, Ying Qin; Le, Yingying1 |
| 刊名 | Diabetes
 |
| 出版日期 | 2010-12-01 |
| 卷号 | 59期号:12页码:3041-3048 |
| ISSN号 | 0012-1797 |
| DOI | 10.2337/db10-0418 |
| 通讯作者 | Le, yingying(yyle@sibs.ac.cn) |
| 英文摘要 | Objective toll-like receptor 4 (tlr4) has been reported to induce insulin resistance through inflammation in high-fat-fed mice. however, the physiological role of tlr4 in metabolism is unknown. here, we investigated the involvement of tlr4 in fasting metabolism. research design and methods wild-type and tlr4 deficient (tlr4(-/-)) mice were either fed or fasted for 24 h. glucose and lipid levels in circulation and tissues were measured. glucose and lipid metabolism in tissues, as well as the expression of related enzymes, was examined. results mice lacking tlr4 displayed aggravated fasting hypoglycemia, along with normal hepatic gluconeogenesis, but reversed activity of pyruvate dehydrogenase complex (pdc) in skeletal muscle, which might account for the fasting hypoglycemia. tlr4(-/-) mice also exhibited higher lipid levels in circulation and skeletal muscle after fasting and reversed expression of lipogenic enzymes in skeletal muscle but not liver and adipose tissue. adipose tissue lipolysis is normal and muscle fatty acid oxidation is increased in tlr4(-/-) mice after fasting. inhibition of fatty acid synthesis in tlr4(-/-) mice abolished hyperlipidemia, hypoglycemia, and pdc activity increase, suggesting that tlr4-dependent inhibition of muscle lipogenesis may contribute to glucose and lipid homeostasis during fasting. further studies showed that tlr4 deficiency had no effect on insulin signaling and muscle proinflammatory cytokine production in response to fasting. conclusions these data suggest that tlr4 plays a critical role in glucose and lipid metabolism independent of insulin during fasting and identify a novel physiological role for tlr4 in fuel homeostasis. diabetes 59:3041-3048, 2010 |
| WOS关键词 | PYRUVATE-DEHYDROGENASE COMPLEX ; FATTY-ACID SYNTHESIS ; INDUCED INSULIN-RESISTANCE ; HEPATIC LIPID-METABOLISM ; DIETARY GLUCOSE CARBON ; WHITE ADIPOSE-TISSUE ; OB-OB MICE ; PPAR-ALPHA ; DIABETES-MELLITUS ; SKELETAL-MUSCLES |
| WOS研究方向 | Endocrinology & Metabolism |
| WOS类目 | Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000285988200009 |
| 出版者 | AMER DIABETES ASSOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413675 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Le, Yingying |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Pang, Shanshan,Tang, Haiqing,Zhuo, Shu,et al. Regulation of fasting fuel metabolism by toll-like receptor 4[J]. Diabetes,2010,59(12):3041-3048. |
| APA | Pang, Shanshan,Tang, Haiqing,Zhuo, Shu,Zang, Ying Qin,&Le, Yingying.(2010).Regulation of fasting fuel metabolism by toll-like receptor 4.Diabetes,59(12),3041-3048. |
| MLA | Pang, Shanshan,et al."Regulation of fasting fuel metabolism by toll-like receptor 4".Diabetes 59.12(2010):3041-3048. |
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来源：中国科学院大学
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