Synthesis of 2-amino-5-hydroxycaprolactam derivatives mediated by e-selective olefination and asymmetric oxidation of the enol ether
文献类型：期刊论文
| 作者 | Li, Hong1,4; Liu, Yingxue1; Liu, Qijun1,4; Hu, Wenhui1; Zhou, Guo-Chun1,2,3 |
| 刊名 | Synthesis-stuttgart
 |
| 出版日期 | 2010-12-01 |
| 期号 | 23页码:4068-4074 |
| 关键词 | Caprolactam E-selective olefination Asymmetric oxidation Enol ether Reductive amination |
| ISSN号 | 0039-7881 |
| DOI | 10.1055/s-0030-1258275 |
| 通讯作者 | Zhou, guo-chun(allspringzhou@yahoo.com) |
| 英文摘要 | The asymmetric synthesis of 2-amino-5-hydroxycaprolactam derivatives is essential for exploring the antitumor properties of ester-bearing bengamides. in this study, chiral caprolactam isomers were achieved on the basis of highly e-selective wittig olefination, asymmetric oxidations of the e-enol ethers, reductive amination of the aldehyde derivatives, cyclization of the 5-hydroxylysine analogues or/and deprotection. |
| WOS关键词 | BENGAMIDE-B ; STEREOSELECTIVE SYNTHESIS ; AMINO-ACIDS ; ANTITUMOR ; SPONGE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000284535900021 |
| 出版者 | GEORG THIEME VERLAG KG |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2413926 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhou, Guo-Chun |
| 作者单位 | 1.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 2.Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 210009, Peoples R China 3.Nanjing Univ Technol, Coll Pharmaceut Sci, Nanjing 210009, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Hong,Liu, Yingxue,Liu, Qijun,et al. Synthesis of 2-amino-5-hydroxycaprolactam derivatives mediated by e-selective olefination and asymmetric oxidation of the enol ether[J]. Synthesis-stuttgart,2010(23):4068-4074. |
| APA | Li, Hong,Liu, Yingxue,Liu, Qijun,Hu, Wenhui,&Zhou, Guo-Chun.(2010).Synthesis of 2-amino-5-hydroxycaprolactam derivatives mediated by e-selective olefination and asymmetric oxidation of the enol ether.Synthesis-stuttgart(23),4068-4074. |
| MLA | Li, Hong,et al."Synthesis of 2-amino-5-hydroxycaprolactam derivatives mediated by e-selective olefination and asymmetric oxidation of the enol ether".Synthesis-stuttgart .23(2010):4068-4074. |
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来源：中国科学院大学
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