Glutamine and animal immune function
文献类型：期刊论文
| 作者 | Yin, Fugui2; Jiang, Weiming1; Guan, Shu3; Pan, Zhizhong1; Chen, Xiuli1; Chen, Xiaohan1 |
| 刊名 | Journal of food agriculture & environment
 |
| 出版日期 | 2010-07-01 |
| 卷号 | 8期号:3-4页码:135-141 |
| 关键词 | Glutamine Immune function Immune cells Cytokines |
| ISSN号 | 1459-0255 |
| 通讯作者 | Chen, xiaohan(chnxhn@163.com) |
| 英文摘要 | This review will attempt to summarize literatures of the relationship between glutamine (gin) and the host's immune function. it will expatiate the connotation of gin as a "nutritional drug" with many important biochemical roles. the clinical recommendations with regard to patients and experimental animals may benefit from different supplying route of gln. scientific studies indicate that gin, traditionally considered a nonessential amino acid, now is considered "conditionally essential" aftercritical illness, stress, and injury. states of illness or injury can lead to a significant decrease in plasma levels of gln, and when this decrease is severe, it has been correlated with increased mortality. researches have demonstrated numerous benefits of gin in experimental models of critical illness, burn, and cardiac injury. the mechanism of these protective effects includes attenuated pro-inflammatory cytokine expression, improved gut barrier function, enhanced ability to mount a stress response, improved immune cell function, and decreased mortality. clinical trials of gin supplementation in critical illness, surgical stress, and cancer have shown benefit with regard to mortality, length of stay, and infectious morbidity. however, literatures demonstrating a lack of benefit with gin supplementation in some patients have been presented as well. no evidence of harm has been observed in studies conducted to reported literatures; thus, further clinical trials using gin as a pharmacological supplement to "nutritional drug" are warranted. |
| WOS关键词 | TOTAL PARENTERAL-NUTRITION ; DIETARY ARGININE SUPPLEMENTATION ; INTESTINAL EPITHELIAL-CELLS ; RESPIRATORY-TRACT IMMUNITY ; AMINO-ACID-CONCENTRATIONS ; GROWING PIGS ; MURINE MACROPHAGES ; HUMAN MONOCYTES ; SEPTIC RATS ; FATTY-ACIDS |
| WOS研究方向 | Food Science & Technology |
| WOS类目 | Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000286039800021 |
| 出版者 | WFL PUBL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2414138 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Xiaohan |
| 作者单位 | 1.Guangxi Inst Fisheries, Nanning 530021, Guangxi, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Ctr Rech Aliments Guelph Agr & Agri Food Canada, Guelph Food Res Ctr, Guelph, ON NIG 5C9, Canada |
| 推荐引用方式 GB/T 7714 | Yin, Fugui,Jiang, Weiming,Guan, Shu,et al. Glutamine and animal immune function[J]. Journal of food agriculture & environment,2010,8(3-4):135-141. |
| APA | Yin, Fugui,Jiang, Weiming,Guan, Shu,Pan, Zhizhong,Chen, Xiuli,&Chen, Xiaohan.(2010).Glutamine and animal immune function.Journal of food agriculture & environment,8(3-4),135-141. |
| MLA | Yin, Fugui,et al."Glutamine and animal immune function".Journal of food agriculture & environment 8.3-4(2010):135-141. |
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来源：中国科学院大学
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