Association between hepatitis b viral burden in chronic infection and a functional single nucleotide polymorphism of the pdcd1 gene
文献类型：期刊论文
| 作者 | Zheng, Linghua1,2; Li, Dongling1; Wang, Fusheng1,3; Wu, Hao4; Li, Xiaozhu1; Fu, Junliang3; Chen, Xinyue4; Wang, Lizhong5; Liu, Yang1,5; Wang, Shengdian1 |
| 刊名 | Journal of clinical immunology
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 30期号:6页码:855-860 |
| 关键词 | Pd-1 Single-nucleotide polymorphism Hepatitis b virus Viral load |
| ISSN号 | 0271-9142 |
| DOI | 10.1007/s10875-010-9450-1 |
| 通讯作者 | Wang, shengdian(sdwang@moon.ibp.ac.cn) |
| 英文摘要 | Background pd-1, encoded by pdcd1, is highly expressed on virus-specific t cells and plays critical roles in modulating anti-virus immune responses in chronic viral infection. it is unknown, however, whether polymorphisms of the pdcd1 are associated with viral clearance during chronic viral infections. methodology and principal findings here, we used the polymerase chain reaction-restriction fragment length polymorphism method to genotype two single nucleotide polymorphisms (snps) of pdcd1 in 502 patients with chronic hepatitis b virus (hbv) infection and 359 healthy controls to determine the association between pdcd1 genotypes and serum viral load as well as the risk of chronic infection. our results showed that although neither the p7209(c/t) snp site nor the p8737(a/g) site was associated with the risk of chronic hbv infection, the p7209(t). allele in intron 4 is significantly associated with lower viral burden in the blood. using a luciferase reporter assay, we demonstrated that the p7209(t) allele creates a negative cis-element for gene transcription. conclusions and significance our data provide the first evidence that pdcd1 polymorphisms is a genetic factor in pathogenesis of chronic viral infection and reveal the functional significance of the p7209 snp of the pdcd1. |
| WOS关键词 | SYSTEMIC-LUPUS-ERYTHEMATOSUS ; VIRUS-INFECTION ; RHEUMATOID-ARTHRITIS ; REGULATORY POLYMORPHISM ; PD-1 GENE ; T-CELLS ; SUSCEPTIBILITY ; CLEARANCE ; HAPLOTYPE ; IMMUNITY |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000284249300011 |
| 出版者 | SPRINGER/PLENUM PUBLISHERS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2414542 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Shengdian |
| 作者单位 | 1.Inst Biophys, Key Lab Infect & Immun, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100101, Peoples R China 3.Beijing 302 Hosp, Res Ctr Biol Therapy, Beijing Inst Infect Dis, Beijing 100039, Peoples R China 4.Capital Med Univ, Dept Infect Dis, Beijing You An Hosp, Beijing 100054, Peoples R China 5.Univ Michigan, Div Immunotherapy, Ann Arbor, MI 48109 USA |
| 推荐引用方式 GB/T 7714 | Zheng, Linghua,Li, Dongling,Wang, Fusheng,et al. Association between hepatitis b viral burden in chronic infection and a functional single nucleotide polymorphism of the pdcd1 gene[J]. Journal of clinical immunology,2010,30(6):855-860. |
| APA | Zheng, Linghua.,Li, Dongling.,Wang, Fusheng.,Wu, Hao.,Li, Xiaozhu.,...&Wang, Shengdian.(2010).Association between hepatitis b viral burden in chronic infection and a functional single nucleotide polymorphism of the pdcd1 gene.Journal of clinical immunology,30(6),855-860. |
| MLA | Zheng, Linghua,et al."Association between hepatitis b viral burden in chronic infection and a functional single nucleotide polymorphism of the pdcd1 gene".Journal of clinical immunology 30.6(2010):855-860. |
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来源：中国科学院大学
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