Dishevelled: the hub of wnt signaling
文献类型：期刊论文
| 作者 | Gao, Chan; Chen, Ye-Guang |
| 刊名 | Cellular signalling
 |
| 出版日期 | 2010-05-01 |
| 卷号 | 22期号:5页码:717-727 |
| 关键词 | Dishevelled Wnt Beta-catenin Planar cell polarity Development |
| ISSN号 | 0898-6568 |
| DOI | 10.1016/j.cellsig.2009.11.021 |
| 通讯作者 | Chen, ye-guang(ygchen@tsinghua.edu.cn) |
| 英文摘要 | Wnt signaling controls a variety of developmental and homeostatic events. as a key component of wnt signaling, dishevelled (dvl/dsh) protein relays wnt signals from receptors to downstream effectors. in the canonical wnt pathway that depends on the nuclear translocation of beta-catenin, do is recruited by the receptor frizzled and prevents the constitutive destruction of cytosolic beta-catenin. in the non-canonical writ pathways such as wnt-frizzled/pcp (planar cell polarity) signaling, do signals via the daam1-rhoa axis and the rac1 axis. in addition, do plays important roles in wnt-gsk3 beta-microtubule signaling, wnt-calcium signaling, wnt-ryk signaling, wnt-atypical pkc signaling, etc. dvl also functions to mediate receptor endocytosis. to fulfill its multifaceted functions, it is not surprising that do associates with various kinds of proteins. its activity is also modulated dynamically by phosphorylation, ubiquitination and degradation. in this review, we summarize the current understanding of do functions in wnt signal transduction and its biological functions in mouse development, and also discuss the molecular mechanisms of its actions. (c) 2009 elsevier inc. all rights reserved. |
| WOS关键词 | PLANAR CELL-POLARITY ; WNT/BETA-CATENIN PATHWAY ; GLYCOGEN-SYNTHASE KINASE-3-BETA ; CONVERGENT EXTENSION MOVEMENTS ; CILIATED EPITHELIAL-CELLS ; ANTAGONIST NAKED CUTICLE ; COLORECTAL-CANCER CELLS ; DVL-BINDING PROTEIN ; NEURAL-TUBE CLOSURE ; KINASE-I-EPSILON |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000275984600002 |
| 出版者 | ELSEVIER SCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2414645 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Ye-Guang |
| 作者单位 | Tsinghua Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Chan,Chen, Ye-Guang. Dishevelled: the hub of wnt signaling[J]. Cellular signalling,2010,22(5):717-727. |
| APA | Gao, Chan,&Chen, Ye-Guang.(2010).Dishevelled: the hub of wnt signaling.Cellular signalling,22(5),717-727. |
| MLA | Gao, Chan,et al."Dishevelled: the hub of wnt signaling".Cellular signalling 22.5(2010):717-727. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。