Collagen scaffolds loaded with collagen-binding ngf-beta accelerate ulcer healing
文献类型：期刊论文
| 作者 | Sun, Wenjie1,2; Lin, Hang1; Chen, Bing1; Zhao, Wenxue1; Zhao, Yannan1; Xiao, Zhifeng1; Dai, Jianwu1 |
| 刊名 | Journal of biomedical materials research part a
 |
| 出版日期 | 2010-03-01 |
| 卷号 | 92a期号:3页码:887-895 |
| 关键词 | Nerve growth factor Collagen-binding domain Ulcer healing Peripheral nerve growth Targeting delivers system |
| ISSN号 | 1549-3296 |
| DOI | 10.1002/jbm.a.32445 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Studies have shown that exogenous nerve growth factor (ngf) accelerates ulcer healing, but the inefficient growth factor delivery system limits its clinical application. in this report, we found that the native human ngf-beta fused with a collagen-binding domain (cbd) could form a collagen-based ngf targeting delivery system, and the cbd-fused ngf-beta could bind to collagen membranes efficiently. using the rabbit dermal ischemic ulcer model, we have found that this targeting delivery system maintains a higher concentration and stronger bioactivity of ngf-beta on the collagen membranes by promoting peripheral nerve growth. furthermore, it enhances the rate of ulcer healing through accelerating the re-epithelialization of dermal ulcer wounds and the formation of capillary lumens within the newly formed tissue area. thus, collagen membranes loaded with collagen-targeting human ngf-beta accelerate ulcer healing efficiently. (c) 2009 wiley periodicals, inc. j biomed mater res 92a: 887-895, 2010 |
| WOS关键词 | NERVE-GROWTH-FACTOR ; DIABETIC MICE ; TOPICAL APPLICATION ; PRESSURE ULCERS ; RABBIT EAR ; MODEL ; ANGIOGENESIS ; REGENERATION ; MECHANISMS ; ISCHEMIA |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000274307600008 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2415041 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Wenjie,Lin, Hang,Chen, Bing,et al. Collagen scaffolds loaded with collagen-binding ngf-beta accelerate ulcer healing[J]. Journal of biomedical materials research part a,2010,92a(3):887-895. |
| APA | Sun, Wenjie.,Lin, Hang.,Chen, Bing.,Zhao, Wenxue.,Zhao, Yannan.,...&Dai, Jianwu.(2010).Collagen scaffolds loaded with collagen-binding ngf-beta accelerate ulcer healing.Journal of biomedical materials research part a,92a(3),887-895. |
| MLA | Sun, Wenjie,et al."Collagen scaffolds loaded with collagen-binding ngf-beta accelerate ulcer healing".Journal of biomedical materials research part a 92a.3(2010):887-895. |
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来源：中国科学院大学
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