Expression of ifn alpha-inducible genes and modulation of hla-dr and thyroid stimulating hormone receptors in graves' disease
文献类型：期刊论文
| 作者 | Miao Kuang1; Shu Wang1,2; Miao Wu1; Guang Ning1,2; Yao, Zhengbin1; Li, Lixin1 |
| 刊名 | Molecular and cellular endocrinology
 |
| 出版日期 | 2010-05-05 |
| 卷号 | 319期号:1-2页码:23-29 |
| 关键词 | Ifn alpha Graves' disease Ifn alpha-inducible genes Tshr, hla-dr |
| ISSN号 | 0303-7207 |
| DOI | 10.1016/j.mce.2009.12.006 |
| 通讯作者 | Shu wang() |
| 英文摘要 | Interferon alpha (ifn alpha) plays an important role in the pathogenesis of different autoimmune diseases. ifn alpha is widely used for the treatment of chronic viral infections, particularly chronic hepatitis c virus infection: however, several case reports have emerged describing autoimmune conditions, such as graves' disease (gd). that have developed in the patients receiving ifn alpha. the mechanism by which ifn alpha is involved in gd remains poorly understood we investigated the expression of ifn alpha and ifn alpha-inducible genes (ifigs) in gd and found that ifigs were overexpressed in 60% of 54 clinical diagnostic gd patients these elevated ifigs correlated with serological levels of autoantibody to thyroid stimulating hormone receptor (tshr) recombinant human ifn alpha stimulated primary cultured thyrocytes resulted in not only high level expression of ifigs. but also, more importantly, expression of mhc-ii antigens (hla-dr3 and hla-dr5) and tshr in gd subjects furthermore, thyroid gland tissues from gd patients over express hla-dr. tshr and ifn alpha receptors at both messenger rna and protein levels taken together, these data indicated that in gd patients. ifn alpha can function on thyroid tissue to induce a number of genes, particularly mhc class ii molecules which may enhance autoantigen presentation of tshr on thyrocytes (c) 2010 published by elsevier ireland ltd |
| WOS关键词 | SYSTEMIC-LUPUS-ERYTHEMATOSUS ; INTERFERON-ALPHA ; VIRUS INTERFERENCE ; FOLLICULAR CELLS ; ANTIVIRAL STATE ; MX PROTEINS ; AUTOIMMUNITY ; THERAPY ; ANTIGEN ; GLAND |
| WOS研究方向 | Cell Biology ; Endocrinology & Metabolism |
| WOS类目 | Cell Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000276438000004 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2415305 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shu Wang |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Hlth Sci, Shanghai Inst Biol Sci, Med Sch,Chinese Acad Sci, Shanghai 200025, Peoples R China 2.Shanghai Jiao Tong Univ, Grad Sch, Chinese Acad Sci, Dept Endocrinol & Metab,Ruijing Hosp, Shanghai 200025, Peoples R China |
| 推荐引用方式 GB/T 7714 | Miao Kuang,Shu Wang,Miao Wu,et al. Expression of ifn alpha-inducible genes and modulation of hla-dr and thyroid stimulating hormone receptors in graves' disease[J]. Molecular and cellular endocrinology,2010,319(1-2):23-29. |
| APA | Miao Kuang,Shu Wang,Miao Wu,Guang Ning,Yao, Zhengbin,&Li, Lixin.(2010).Expression of ifn alpha-inducible genes and modulation of hla-dr and thyroid stimulating hormone receptors in graves' disease.Molecular and cellular endocrinology,319(1-2),23-29. |
| MLA | Miao Kuang,et al."Expression of ifn alpha-inducible genes and modulation of hla-dr and thyroid stimulating hormone receptors in graves' disease".Molecular and cellular endocrinology 319.1-2(2010):23-29. |
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来源：中国科学院大学
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