Preparation and sustained-release property of triblock copolymer/calcium phosphate nanocomposite as nanocarrier for hydrophobic drug
文献类型：期刊论文
| 作者 | Cao, Shao-Wen1,2; Zhu, Ying-Jie1,2; Wu, Jin1,2; Wang, Ke-Wei1,2; Tang, Qi-Li1,2 |
| 刊名 | Nanoscale research letters
 |
| 出版日期 | 2010-04-01 |
| 卷号 | 5期号:4页码:781-785 |
| 关键词 | Nanocomposite P123 Calcium phosphate Hydrophobic drug Sustained release |
| ISSN号 | 1931-7573 |
| DOI | 10.1007/s11671-010-9558-5 |
| 通讯作者 | Zhu, ying-jie(y.j.zhu@mail.sic.ac.cn) |
| 英文摘要 | The p123/acp nanocomposite with sizes less than 100 nm consisting of triblock copolymer p123 and amorphous calcium phosphate (acp) has been prepared by using an aqueous solution containing cacl(2), (nh(4))(3)po(4), and p123 at room temperature. the p123/acp nanocomposite is used as the nanocarrier for hydrophobic drug ibuprofen, based on the combined advantages of both amphiphilic block copolymer and calcium phosphate delivery system. the p123/acp nanocomposite has a much higher ibuprofen loading capacity (148 mg/g) than the single-phase calcium phosphate nanostructures. the drug release percentage of the p123/acp nanocomposite in simulated body fluid reaches about 100% in a period of 156 h, which is much slower than that of single-phase calcium phosphate nanostructures. it is expected that the p123/acp nanocomposite is promising for the application in the controlled delivery of hydrophobic drugs. |
| WOS关键词 | BLOCK-COPOLYMER ; GENE DELIVERY ; NONVIRAL VECTORS ; NANOPARTICLES ; MICELLES ; P123 ; PARTICLES ; MOLECULES ; CELLS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| 语种 | 英语 |
| WOS记录号 | WOS:000276435500017 |
| 出版者 | SPRINGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2415327 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhu, Ying-Jie |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab High Performance Ceram & Superfine, Shanghai Inst Ceram, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Shao-Wen,Zhu, Ying-Jie,Wu, Jin,et al. Preparation and sustained-release property of triblock copolymer/calcium phosphate nanocomposite as nanocarrier for hydrophobic drug[J]. Nanoscale research letters,2010,5(4):781-785. |
| APA | Cao, Shao-Wen,Zhu, Ying-Jie,Wu, Jin,Wang, Ke-Wei,&Tang, Qi-Li.(2010).Preparation and sustained-release property of triblock copolymer/calcium phosphate nanocomposite as nanocarrier for hydrophobic drug.Nanoscale research letters,5(4),781-785. |
| MLA | Cao, Shao-Wen,et al."Preparation and sustained-release property of triblock copolymer/calcium phosphate nanocomposite as nanocarrier for hydrophobic drug".Nanoscale research letters 5.4(2010):781-785. |
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来源：中国科学院大学
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