Folding network of villin headpiece subdomain
文献类型：期刊论文
| 作者 | Lei, Hongxing1,3,4; Su, Yao1,2; Jin, Lian1; Duan, Yong3,4,5 |
| 刊名 | Biophysical journal
 |
| 出版日期 | 2010-11-17 |
| 卷号 | 99期号:10页码:3374-3384 |
| ISSN号 | 0006-3495 |
| DOI | 10.1016/j.bpj.2010.08.081 |
| 通讯作者 | Lei, hongxing(leihx@big.ac.cn) |
| 英文摘要 | Protein folding is a complex multidimensional process that is difficult to illustrate by the traditional analyses based on one- or two-dimensional profiles. analyses based on transition networks have become an alternative approach that has the potential to reveal detailed features of protein folding dynamics. however, due to the lack of successful reversible folding of proteins from conventional molecular-dynamics simulations, this approach has rarely been utilized. here, we analyzed the folding network from several 10 mu s conventional molecular-dynamics reversible folding trajectories of villin headpiece subdomain (hp35). the folding network revealed more complexity than the traditional two-dimensional map and demonstrated a variety of conformations in the unfolded state, intermediate states, and the native state. of note, deep enthalpic traps at the unfolded state were observed on the folding landscape. furthermore, in contrast to the clear separation of the native state and the primary intermediate state shown on the two-dimensional map, the two states were mingled on the folding network, and prevalent interstate transitions were observed between these two states. a more complete picture of the folding mechanism of hp35 emerged when the traditional and network analyses were considered together. |
| WOS关键词 | MOLECULAR-DYNAMICS SIMULATIONS ; FREE-ENERGY LANDSCAPE ; FORCE-FIELD ; PROTEIN ; PATHWAYS ; STATE ; INTERMEDIATE ; RESONANCE ; ENSEMBLE ; SURFACES |
| WOS研究方向 | Biophysics |
| WOS类目 | Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000284438700032 |
| 出版者 | CELL PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2415400 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Lei, Hongxing |
| 作者单位 | 1.Chinese Acad Sci, Beijing Inst Genom, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Univ Calif Davis, UC Davis Genome Ctr, Davis, CA 95616 USA 4.Univ Calif Davis, Dept Appl Sci, Davis, CA 95616 USA 5.Huazhong Univ Sci & Technol, Coll Phys, Wuhan 430074, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, Hongxing,Su, Yao,Jin, Lian,et al. Folding network of villin headpiece subdomain[J]. Biophysical journal,2010,99(10):3374-3384. |
| APA | Lei, Hongxing,Su, Yao,Jin, Lian,&Duan, Yong.(2010).Folding network of villin headpiece subdomain.Biophysical journal,99(10),3374-3384. |
| MLA | Lei, Hongxing,et al."Folding network of villin headpiece subdomain".Biophysical journal 99.10(2010):3374-3384. |
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来源：中国科学院大学
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