Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes
文献类型：期刊论文
| 作者 | Wang, Kai1,2; Li, Xiao-Qian3; Li, Xiao-Xin1,2; Pei, Wei-Hua3; Chen, Hong-Da3; Dong, Jian-Qiang4 |
| 刊名 | Vision research
 |
| 出版日期 | 2011-09-01 |
| 卷号 | 51期号:17页码:1897-1906 |
| 关键词 | Animal testing Visual prosthesis Microelectrode Optic nerve Evoked potentials |
| ISSN号 | 0042-6989 |
| DOI | 10.1016/j.visres.2011.06.019 |
| 通讯作者 | Li, xiao-xin(drxiaoxinli@gmail.com) |
| 英文摘要 | In addition to epiretinal and subretinal areas, the optic nerve (on) is also a candidate location for implanting visual prosthesis to restore vision of patients with retinitis pigmentosa (rp). since the on receives all the signals from the retina, stimulating the on may potentially evoke phosphenes over a wider range of visual field. in this study, we designed a 9-channel microelectrode array and implanted it between the dura mater and pia mater of rabbit ons by lateral orbitotomy. we recorded the current thresholds and evaluated the efficacy of the array using electrically evoked potentials (eeps). spatial discrimination of approximately 20 was verified by eep maps over visual cortex. a large area of the visual field (over 130 along horizontal meridian) could be activated by this microelectrode array. visual evoked potentials (veps) and different pathological examinations were used to examine potential damage of ons. one year post implantation, we did not notice significant damages to either the ons or the microelectrode arrays. eeps were successfully recorded up to 6 months post implantations. however, further studies are still needed to reduce fibrous encapsulation of the microelectrode array, which resulted in a gradual elevation of current thresholds to elicit eeps. (c) 2011 elsevier ltd. all rights reserved. |
| WOS关键词 | ELECTRICAL-STIMULATION ; RETINITIS-PIGMENTOSA ; EVOKED-POTENTIALS ; ARTIFICIAL VISION ; VISUAL-CORTEX ; INNER RETINA ; PROSTHESIS ; ELECTRODE ; CELL ; ABNORMALITIES |
| WOS研究方向 | Neurosciences & Neurology ; Ophthalmology |
| WOS类目 | Neurosciences ; Ophthalmology |
| 语种 | 英语 |
| WOS记录号 | WOS:000294833000002 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2428164 |
| 专题 | 半导体研究所 |
| 通讯作者 | Li, Xiao-Xin |
| 作者单位 | 1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China 2.Minist Educ, Lab Vis Loss & Restorat, Beijing 100034, Peoples R China 3.Chinese Acad Sci, Inst Semicond, Beijing 100083, Peoples R China 4.Peking Univ, Peoples Hosp, Dept Pathol, Cent Lab, Beijing 100044, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kai,Li, Xiao-Qian,Li, Xiao-Xin,et al. Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes[J]. Vision research,2011,51(17):1897-1906. |
| APA | Wang, Kai,Li, Xiao-Qian,Li, Xiao-Xin,Pei, Wei-Hua,Chen, Hong-Da,&Dong, Jian-Qiang.(2011).Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes.Vision research,51(17),1897-1906. |
| MLA | Wang, Kai,et al."Efficacy and reliability of long-term implantation of multi-channel microelectrode arrays in the optical nerve sheath of rabbit eyes".Vision research 51.17(2011):1897-1906. |
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来源：半导体研究所
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