Synthesis and antimicrobial activities of novel peptide deformylase inhibitors
文献类型：期刊论文
| 作者 | Yin, Ling ; Xu, Wei-Ren ; Wang, Zhi-Guo ; Zhang, Da-Tong ; Jia, Jiong ; Ge, Yan-Qing ; Li, Yan ; Wang, Jian-Wu |
| 刊名 | ARKIVOC
 ; Yin, L; Xu, WR; Wang, ZG; Zhang, DT; Jia, JO; Ge, YQ; Li, Y; Wang, JW.Synthesis and antimicrobial activities of novel peptide deformylase inhibitors,ARKIVOC,2010,():196-205
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| 出版日期 | 2010 |
| 英文摘要 | A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro.; A new series of N-formylhydroxylamine compounds were designed, optimized with the AutoDock 4.0.1 to investigate the interactions between the target compounds and the amino acid residues of the Escherichia coli PDF center dot Ni enzyme, and then synthesized through multi-step sequence starting from diethyl malonate. The structures of the compounds were characterized on the basis of spectral (FT-IR, 1H NMR and mass) analysis. All the synthesized compounds have been screened for their antimicrobial activities. It was found that the compounds 11c, 11d, 11f and 11g exhibited potent inhibitory activity against S. aureus in vitro. |
| 源URL | [http://ir.nwipb.ac.cn//handle/363003/1784]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Yin, Ling,Xu, Wei-Ren,Wang, Zhi-Guo,et al. Synthesis and antimicrobial activities of novel peptide deformylase inhibitors[J]. ARKIVOC, Yin, L; Xu, WR; Wang, ZG; Zhang, DT; Jia, JO; Ge, YQ; Li, Y; Wang, JW.Synthesis and antimicrobial activities of novel peptide deformylase inhibitors,ARKIVOC,2010,():196-205,2010. |
| APA | Yin, Ling.,Xu, Wei-Ren.,Wang, Zhi-Guo.,Zhang, Da-Tong.,Jia, Jiong.,...&Wang, Jian-Wu.(2010).Synthesis and antimicrobial activities of novel peptide deformylase inhibitors.ARKIVOC. |
| MLA | Yin, Ling,et al."Synthesis and antimicrobial activities of novel peptide deformylase inhibitors".ARKIVOC (2010). |
入库方式： OAI收割
来源：西北高原生物研究所
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