Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals
文献类型：期刊论文
| 作者 | Liu, Zhen ; Wang, Wei ; Zhang, Tong-Zuo ; Li, Gong-Hua ; He, Kai ; Huang, Jing-Fei ; Jiang, Xue-Long ; Murphy, Robert W. ; Shi, Peng |
| 刊名 | PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
 ; Liu, Z; Wang, W; Zhang, TZ; Li, GH; He, K; Huang, JF; Jiang, XL; Murphy, RW; Shi, P.Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals,PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776):
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| 出版日期 | 2014-02-07 |
| 英文摘要 | Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals.; Hibernating mammals need to be insensitive to acid in order to cope with conditions of high CO2; however, the molecular basis of acid tolerance remains largely unknown. The African naked mole-rat (Heterocephalus glaber) and hibernating mammals share similar environments and physiological features. In the naked mole-rat, acid insensitivity has been shown to be conferred by the functional motif of the sodium ion channel Na(V)1.7. There is now an opportunity to evaluate acid insensitivity in other taxa. In this study, we tested for functional convergence of Na(V)1.7 in 71 species of mammals, including 22 species that hibernate. Our analyses revealed a functional convergence of amino acid sequences, which occurred at least six times independently in mammals that hibernate. Evolutionary analyses determined that the convergence results from both parallel and divergent evolution of residues in the functional motif. Our findings not only identify the functional molecules responsible for acid insensitivity in hibernating mammals, but also open new avenues to elucidate the molecular underpinnings of acid insensitivity in mammals. |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/4253]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Zhen,Wang, Wei,Zhang, Tong-Zuo,et al. Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Liu, Z; Wang, W; Zhang, TZ; Li, GH; He, K; Huang, JF; Jiang, XL; Murphy, RW; Shi, P.Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals,PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES,2014,281(1776):,2014. |
| APA | Liu, Zhen.,Wang, Wei.,Zhang, Tong-Zuo.,Li, Gong-Hua.,He, Kai.,...&Shi, Peng.(2014).Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals.PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES. |
| MLA | Liu, Zhen,et al."Repeated functional convergent effects of Na(V)1.7 on acid insensitivity in hibernating mammals".PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2014). |
入库方式： OAI收割
来源：西北高原生物研究所
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