Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry
文献类型：期刊论文
| 作者 | Wang, Hailiang ; Gao, Tingting ; Du, Yuzhi ; Yang, Hongxia ; Wei, Lixin ; Bi, Hongtao ; Ni, Weihua |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2015-10-20 |
| 英文摘要 | Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1 -> 4)-beta-D-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (C) 2015 Elsevier Ltd. All rights reserved.; Our previous study isolated an anti-fatigue polysaccharide (HRWP) from the Hippophae rhamnoides berry. In this study, using ion-exchange chromatography and gel filtration chromatography in turn, a watersoluble homogenous polysaccharide HRWP-A was isolated from HRWP. Structural analysis determined that HRWP-A was a polysaccharide with repeating units of (1 -> 4)-beta-D-galactopyranosyluronic residues, of which 85.16% were esterified with methyl groups. An antitumor activity assay showed that HRWP-A could significantly inhibit the Lewis lung carcinoma (LLC) growth in tumor-bearing mice. Further experiments suggested that the antitumor effect of HRWP-A might be mediated through immunostimulating activity, as it enhances the lymphocyte proliferation, augments the macrophage activities, as well as promoting NK cell activity and CTL cytotoxicity in tumor-bearing mice. To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (C) 2015 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/5494]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Hailiang,Gao, Tingting,Du, Yuzhi,et al. Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry[J]. CARBOHYDRATE POLYMERS,2015. |
| APA | Wang, Hailiang.,Gao, Tingting.,Du, Yuzhi.,Yang, Hongxia.,Wei, Lixin.,...&Ni, Weihua.(2015).Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry.CARBOHYDRATE POLYMERS. |
| MLA | Wang, Hailiang,et al."Anticancer and immunostimulating activities of a novel homogalacturonan from Hippophae rhamnoides L. berry".CARBOHYDRATE POLYMERS (2015). |
入库方式： OAI收割
来源：西北高原生物研究所
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