Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products
文献类型：期刊论文
| 作者 | Wei, Lixin4 ; Gao, Tingting1; Du, Yuzhi1,4; Xia, Zhenghua4; Yang, Hongxia1,4; Song, Jiayin2; Bi, Hongtao4; Ma, Jianbin3; Zhang, Ming4
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| 刊名 | FOOD & FUNCTION
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| 出版日期 | 2017-08-01 |
| 卷号 | 8期号:8页码:2771-2782 |
| ISSN号 | 2042-6496 |
| DOI | 10.1039/c7fo00569e |
| 文献子类 | Article |
| 英文摘要 | The Nitraria tangutorum Bobr. fruit is an indigenous berry of the shrub belonging to the Zygophyllaceae family which grows at an altitude of over 3000 m in the Tibetan Plateau, and has been used as a native medicinal food for treating weakness of the spleen, stomach syndrome, dyspepsia, neurasthenia, dizziness, etc. for thousands of years. Nowadays, N. tangutorum industrial juice by-products generated from health food production can be a potential low cost source of some unique bioactive ingredients. In a prior study, we established a simultaneous microwave/ultrasonic assisted enzymatic extraction method for extracting antioxidant ingredients from the industrial by-products of N. tangutorum juice. In this study, these ingredients were selectively fractionated by cation-exchange resin chromatography to obtain an anthocyanin fraction namely NJBAE. NJBAE was found to be composed of 16 anthocyanins derived from six anthocyanidins by HPLC-ESI-MS, and has an appreciable cardioprotective effect on doxorubicin-induced injured H9c2 cardiomyocytes. The cardioprotective mechanism research showed that NJBAE could directly scavenge ROS, restrict further generation of ROS, promote the activity of key antioxidase, enhance glutathione redox cycling, then affect the apoptotic signaling changes in a positive way, and finally mediate caspase-dependent cell death pathways. Therefore, NJBAE has great potential to be used for preventing and treating cardiovascular disease in the food, pharmaceutical and other emerging industries. |
| WOS关键词 | TANDEM MASS-SPECTROMETRY ; IN-VITRO ; LIQUID-CHROMATOGRAPHY ; ANTIOXIDANT ACTIVITY ; MEDICINAL-PLANTS ; OXIDATIVE STRESS ; TIBETAN PLATEAU ; HPLC-MS ; DOXORUBICIN ; GRAPE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Food Science & Technology |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000407768600014 |
| 资助机构 | National Natural Science Foundation of China(31400310 ; CAS "Light of West China" Program ; Applying Basic Research Program of Qinghai province(2015-ZJ-727) ; Key Laboratory Special Development Program of Qinghai Province(2017-ZJ-Y08) ; Natural Science Foundation of Tianjin City(15JCQNJC07500) ; 51408405) |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/9798]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 通讯作者 | Wei, Lixin; Gao, Tingting; Bi, Hongtao |
| 作者单位 | 1.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining, Qinghai, Peoples R China 2.Tianjin Univ, Tianjin Key Lab Architectural Phys & Environm Tec, Tianjin, Peoples R China 3.Qinghai Normal Univ, Sch Life & Geog Sci, Xining, Qinghai, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Lixin,Gao, Tingting,Du, Yuzhi,et al. Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products[J]. FOOD & FUNCTION,2017,8(8):2771-2782. |
| APA | Wei, Lixin.,Gao, Tingting.,Du, Yuzhi.,Xia, Zhenghua.,Yang, Hongxia.,...&Zhang, Ming.(2017).Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products.FOOD & FUNCTION,8(8),2771-2782. |
| MLA | Wei, Lixin,et al."Characterization and cardioprotective activity of anthocyanins from Nitraria tangutorum Bobr. by-products".FOOD & FUNCTION 8.8(2017):2771-2782. |
入库方式： OAI收割
来源：西北高原生物研究所
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