Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii
文献类型：期刊论文
| 作者 | Pan, Li ; Zhou, Ping ; Zhang, Xiaofeng ; Peng, Shulin ; Ding, Lisheng ; Qiu, Samuel X. |
| 刊名 | ORGANIC LETTERS
 ; Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778
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| 出版日期 | 2006-06-22 |
| 英文摘要 | Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis.; Two novel rearranged trachylobane diterpenoids, designated as wallichanol A (2) and wallichanol B (3), consisting of an unprecedented pentacyclic skeleton named wallichane with a cyclobutane ring, and a new ent-trachylobane diterpenoid, 3-oxo-ent-trachyloban-17-oic acid (1), were isolated from the roots of Euphorbia wallichii. Their structures were elucidated by comprehensive analysis of 2D-NMR spectroscopic data, with the stereochemistry of 1 confirmed by X-ray crystallographic study. All of these compounds potently block osteoclastogenesis in vitro, suggesting a potential therapeutic application in prevention of osteoporosis. |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/1325]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,et al. Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii[J]. ORGANIC LETTERS, Pan Li,Zhou Ping, Zhang Xiaofeng, Peng Shulin, Ding Lisheng,Qiu Samuel X.Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS,2006,8(13):2775-2778,2006. |
| APA | Pan, Li,Zhou, Ping,Zhang, Xiaofeng,Peng, Shulin,Ding, Lisheng,&Qiu, Samuel X..(2006).Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii.ORGANIC LETTERS. |
| MLA | Pan, Li,et al."Skeleton-rearranged pentacyclic diterpenoids possessing a cyclobutane ring from Euphorbia wallichii".ORGANIC LETTERS (2006). |
入库方式： OAI收割
来源：西北高原生物研究所
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