Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia
文献类型：期刊论文
| 作者 | Liao, Zhi-Xin3; Mo, Zhi-Jian1; Ji, Lan-Ju2; Zuo, Bo3; Huang, Ri-Zhen3; Chen, Hui-Feng3 |
| 刊名 | NATURAL PRODUCT COMMUNICATIONS
 |
| 出版日期 | 2017-11-01 |
| 卷号 | 12期号:11页码:1701-1704 |
| 关键词 | Platanus Acerifolia Flavonol Anti-proliferative Activity Apoptotic Analysis |
| ISSN号 | 1934-578X |
| 文献子类 | Article |
| 英文摘要 | The anti-proliferative activities against five cancer cell lines of two flavonols (1, 2) with unsubstituted B ring isolated from the ethanol extract of the leaves of Platanus acerifolia were investigated. The results showed that compound 1 possessed a noteworthy anti-proliferative activity against MGC-803 cells with an IC50 value of 17.26 +/- 1.04 mu M, and compound 2 was less active than 1 with an IC50 value of 20.29 +/- 1.37 mu M compared with 41.94 +/- 1.58 mu M for the positive control group. In addition, the results of Hoechst 33258 staining, AO/EB staining and annexinV-FITC assays indicated that 1 caused a significant MGC-803 cellular apoptosis in a dose-dependent manner. The further mechanisms showed that compound 1 induced the production of ROS, decreased the mitochondrial membrane potential, and altered pro- and anti-apoptotic proteins, leading to activation of caspase-9 and caspase-3 in the process of cellular apoptosis. The present investigation indicated that compound 1 could be used as a potential anti-cancer candidate. |
| WOS关键词 | BUDS ; CELLS |
| WOS研究方向 | Pharmacology & Pharmacy ; Food Science & Technology |
| 语种 | 英语 |
| WOS记录号 | WOS:000417552000009 |
| 出版者 | NATURAL PRODUCTS INC |
| 资助机构 | State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)(CMEMR2016-B06) |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13278]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 通讯作者 | Liao, Zhi-Xin |
| 作者单位 | 1.Jiangsu Jingyuan Biol Engn Co Ltd, Zhenjiang 212100, Peoples R China 2.Chinese Acad Sci, Northwest Inst Plateau Biol, Xining 810008, Qinghai, Peoples R China 3.Southeast Univ, Dept Pharmaceut Engn, Sch Chem & Chem Engn, Nanjing 211189, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liao, Zhi-Xin,Mo, Zhi-Jian,Ji, Lan-Ju,et al. Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia[J]. NATURAL PRODUCT COMMUNICATIONS,2017,12(11):1701-1704. |
| APA | Liao, Zhi-Xin,Mo, Zhi-Jian,Ji, Lan-Ju,Zuo, Bo,Huang, Ri-Zhen,&Chen, Hui-Feng.(2017).Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia.NATURAL PRODUCT COMMUNICATIONS,12(11),1701-1704. |
| MLA | Liao, Zhi-Xin,et al."Anti-proliferative Activities of Two Flavonols with Unsubstituted B-ring from the Leaves of Platanus acerifolia".NATURAL PRODUCT COMMUNICATIONS 12.11(2017):1701-1704. |
入库方式： OAI收割
来源：西北高原生物研究所
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