Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy
文献类型：期刊论文
| 作者 | Zeng, Xin1; He, Nongyue2; Zhang, Gen8; Pu, Maomao8; He, Dacheng3; Zhao, Xiaohui4; Yang, Haowen5; Sun, Jie6,7; Wu, Yi-Zhou8 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2018-01-10 |
| 卷号 | 10期号:1页码:105-113 |
| 关键词 | Nanocrystal Albumin Biosynthesis Cardiovascular System Mammal |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.7b13691 |
| 文献子类 | Article |
| 英文摘要 | The biosynthesis of nanoparticles in bioreactors using microbial, plant, or animal cells is at the forefront of nanotechnology. We demonstrated for the first time that luminescent, water-soluble ZnO nanocrystals (bio-ZnO NCs) can be spontaneously biosynthesized in the mammalian blood circulation, not in cells, when animals were fed with Zn(CH3COO)(2) aqueous solution. Serum albumin, rather than metallothioneins or glutathione, proved to play the pivotal role in biosynthesis. The bio-ZnO NCs were gradually taken up in the liver and degraded and excreted in the urine. Thus, we propose that in mammals such as rodents, bovinae, and humans, excess metal ions absorbed into the cardiovascular system via the intestine can be transformed into nanoparticles by binding to serum albumin, forming a "provisional metal-pool", to reduce the toxicity of free metal ions at high concentration and regulate metal homeostasis in the body. Furthermore, the bio-ZnO NCs, which showed favorable biocompatibility, were functionalized with the anticancer drug daunorubicin and effectively achieved controlled drug release mediated by intracellular glutathione in tumor xenograft mice. |
| WOS关键词 | ZINC-OXIDE NANOPARTICLES ; CELL ; DELIVERY ; ALBUMIN ; METALLOTHIONEIN ; TOXICITY ; COUPLE ; HPLC ; QDS |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000422814400017 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | Jiangsu Provincial Key Research and Development Program(BE2016620) ; Natural Science Foundation of Jiangsu Province(BK20171050) ; Natural Science Foundation of the Jiangsu Higher Education Institutions(17KJB310006) ; Jiangsu Planned Projects for Postdoctoral Research Funds(1601010C) ; Medical Science and Technology Development Foundation of Nanjing Department of Health(JQX15010) ; Nanjing Medical Science and Technique Development Foundation(QRX17072) |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13292]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 通讯作者 | Zeng, Xin; He, Nongyue; Zhang, Gen |
| 作者单位 | 1.Nanjing Med Univ, Obstet & Gynecol Hosp, Nanjing Matern & Child Hlth Med Inst, Nanjing 210004, Jiangsu, Peoples R China 2.Southeast Univ, Dept Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China 3.Beijing Normal Univ, Coll Life Sci, Dept Cell Biol, Beijing 100875, Peoples R China 4.Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810001, Qinghai, Peoples R China 5.ETH, Inst Chem & Bioengn, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland 6.Nanjing Med Univ, Safety Assessment & Res Ctr Drug Pesticide & Vet, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China 7.Nanjing Med Univ, Ctr Hygien Anal & Detect, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China 8.Nanjing Med Univ, Sch Basic Med, Dept Cell Biol, Nanjing 211166, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zeng, Xin,He, Nongyue,Zhang, Gen,et al. Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2018,10(1):105-113. |
| APA | Zeng, Xin.,He, Nongyue.,Zhang, Gen.,Pu, Maomao.,He, Dacheng.,...&Wu, Yi-Zhou.(2018).Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy.ACS APPLIED MATERIALS & INTERFACES,10(1),105-113. |
| MLA | Zeng, Xin,et al."Biosynthetic Mechanism of Luminescent ZnO Nanocrystals in the Mammalian Blood Circulation and Their Functionalization for Tumor Therapy".ACS APPLIED MATERIALS & INTERFACES 10.1(2018):105-113. |
入库方式： OAI收割
来源：西北高原生物研究所
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