ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample
文献类型：期刊论文
| 作者 | Huang, Lunjie ; Chen, Kai ; Zhang, Wentao ; Zhu, Wenxin ; Liu, Xinnan ; Wang, Jing ; Wang, Rong ; Hu, Na ; Suo, Yourui ; Wang, Jianlong |
| 刊名 | SENSORS AND ACTUATORS B-CHEMICAL
 |
| 出版日期 | 2018-09-15 |
| 英文摘要 | Nanozyme technique with efficient modulating strategies is a promising tool for biocatalytic and biosensing applications, yet insights into target-responsive controllability of oxidase nanozymes remain largely unknown. In this contribution, we report a state-of-art oxidase-like and ssDNA-tunable nanozyme for biomolecular recognition. In detail, the spinel-type manganese cation substituted cobalt oxide (MnCo2O4) submicrospheres can imitate oxidase for efficiently catalytic oxidation of colorimetric substrate, superior to current metal oxide-based oxidase nanozymes. More importantly, the nanozyme activity of spinel MnCo2O4 can be reversibly inhibited by the attachment/detachment of aptamer strands on MnCo2O4 surface via the aptamer-target binding event, enabling a new colorimetric access for detecting biomolecules. Taking highly toxic ochratoxin A (OTA) as model molecule, we can selectively determine OTA in maize samples with a limit of detection (3 delta/S) of 0.08 ng/mL. The unique nanozyme property of spinel MnCo2O4, together with the principle of our approach, reveals the potential of ssDNA-tailorable oxidase nanozymes in biocatalytic and biosensing fields. (C) 2018 Elsevier B.V. All rights reserved. |
| 出版者 | ELSEVIER SCIENCE SA |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/13792]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Huang, Lunjie,Chen, Kai,Zhang, Wentao,et al. ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample[J]. SENSORS AND ACTUATORS B-CHEMICAL,2018. |
| APA | Huang, Lunjie.,Chen, Kai.,Zhang, Wentao.,Zhu, Wenxin.,Liu, Xinnan.,...&Wang, Jianlong.(2018).ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample.SENSORS AND ACTUATORS B-CHEMICAL. |
| MLA | Huang, Lunjie,et al."ssDNA-tailorable oxidase-mimicking activity of spinel MnCo2O4 for sensitive biomolecular detection in food sample".SENSORS AND ACTUATORS B-CHEMICAL (2018). |
入库方式： OAI收割
来源：西北高原生物研究所
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