Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis
文献类型：期刊论文
| 作者 | Zheng, Wei ; Wang, Qilan ; Lu, Xiaohua ; Shi, Qiangqiang ; Zou, Junhui ; Tao, Yanduo ; Wang, Pu |
| 刊名 | MEDIATORS OF INFLAMMATION
 |
| 出版日期 | 2016 |
| 英文摘要 | Dracocephalum heterophyllum (DH) is a Chinese herbal medicine used in treating hepatitis. However, the protective effects and pharmacological mechanisms of DH in hepatitis are unknown. In this study, we found that pretreatment with DH extract significantly ameliorated liver injury and suppressed the production of inflammatory cytokines, including tumor necrosis factor (TNF-alpha) and interferon-gamma (IFN-gamma) in ConcanavalinA- (ConA-) induced hepatitis (CIH). DH recruitedmore CD11b(+) Gr1(+) myeloid-derived suppressor cells (MDSCs) to the liver and suppressed infiltration of macrophages (Kupffer cells) in the liver. The present work explores DH as an effective hepatoprotective medicine to inhibit inflammation and liver injury caused by hepatitis. |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/6440]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, Wei,Wang, Qilan,Lu, Xiaohua,et al. Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis[J]. MEDIATORS OF INFLAMMATION,2016. |
| APA | Zheng, Wei.,Wang, Qilan.,Lu, Xiaohua.,Shi, Qiangqiang.,Zou, Junhui.,...&Wang, Pu.(2016).Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis.MEDIATORS OF INFLAMMATION. |
| MLA | Zheng, Wei,et al."Protective Effects of Dracocephalum heterophyllum in ConA-Induced Acute Hepatitis".MEDIATORS OF INFLAMMATION (2016). |
入库方式： OAI收割
来源：西北高原生物研究所
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