ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription
文献类型：期刊论文
| 作者 | Qin, Zhen ; Ren, Fangli ; Xu, Xialian ; Ren, Yongming ; Li, Hongge ; Wang, Yinyin ; Zhai, Yonggong ; Chang, Zhijie |
| 刊名 | MOLECULAR AND CELLULAR BIOLOGY
 ; Qin, Z; Ren, FL; Xu, XL; Ren, YM; Li, HG; Wang, YY; Zhai, YG; Chang, ZJ.ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription,MOLECULAR AND CELLULAR BIOLOGY,2009,29(13):3633-3643
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| 出版日期 | 2009-07-01 |
| 英文摘要 | Neuronal differentiation is tightly regulated by a variety of factors. In a search for neuron-specific genes, we identified a highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 is most abundant in the brain and, in particular, is expressed in the developing central nervous system and dorsal root ganglia and localized in the cerebral cortex, hippocampus, and hypothalamic area. During neuronal differentiation of P19 cells induced by retinoic acid (RA), ZNF536 expression is increased at an early stage, and it is maintained at a constant level in later stages. Overexpression of ZNF536 results in an inhibition of RA-induced neuronal differentiation, while depletion or mutation of the ZNF536 gene results in an enhancement of differentiation. We further demonstrated that ZNF536 inhibits expression of neuron-specific marker genes, possibly through the inhibition of RA response element-mediated transcriptional activity, as overexpression of RA receptor alpha can rescue the inhibitory role of ZNF536 in neuronal differentiation and neuron-specific gene expression. Our studies have identified a novel zinc finger protein that negatively regulates neuron differentiation.; Neuronal differentiation is tightly regulated by a variety of factors. In a search for neuron-specific genes, we identified a highly conserved novel zinc finger protein, ZNF536. We observed that ZNF536 is most abundant in the brain and, in particular, is expressed in the developing central nervous system and dorsal root ganglia and localized in the cerebral cortex, hippocampus, and hypothalamic area. During neuronal differentiation of P19 cells induced by retinoic acid (RA), ZNF536 expression is increased at an early stage, and it is maintained at a constant level in later stages. Overexpression of ZNF536 results in an inhibition of RA-induced neuronal differentiation, while depletion or mutation of the ZNF536 gene results in an enhancement of differentiation. We further demonstrated that ZNF536 inhibits expression of neuron-specific marker genes, possibly through the inhibition of RA response element-mediated transcriptional activity, as overexpression of RA receptor alpha can rescue the inhibitory role of ZNF536 in neuronal differentiation and neuron-specific gene expression. Our studies have identified a novel zinc finger protein that negatively regulates neuron differentiation. |
| 源URL | [http://ir.nwipb.ac.cn//handle/363003/1852]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Qin, Zhen,Ren, Fangli,Xu, Xialian,et al. ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription[J]. MOLECULAR AND CELLULAR BIOLOGY, Qin, Z; Ren, FL; Xu, XL; Ren, YM; Li, HG; Wang, YY; Zhai, YG; Chang, ZJ.ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription,MOLECULAR AND CELLULAR BIOLOGY,2009,29(13):3633-3643,2009. |
| APA | Qin, Zhen.,Ren, Fangli.,Xu, Xialian.,Ren, Yongming.,Li, Hongge.,...&Chang, Zhijie.(2009).ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription.MOLECULAR AND CELLULAR BIOLOGY. |
| MLA | Qin, Zhen,et al."ZNF536, a Novel Zinc Finger Protein Specifically Expressed in the Brain, Negatively Regulates Neuron Differentiation by Repressing Retinoic Acid-Induced Gene Transcription".MOLECULAR AND CELLULAR BIOLOGY (2009). |
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来源：西北高原生物研究所
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