Stability Of Adhesion Clusters And Cell Reorientation Under Lateral Cyclic Tension
文献类型：期刊论文
| 作者 | Kong D(孔冬) ; Ji BH(季葆华); Dai LH(戴兰宏)
|
| 刊名 | Biophysical Journal
 |
| 出版日期 | 2008 |
| 页码 | 4034-4044 |
| 通讯作者邮箱 | bhji@tsinghua.edu.cn ; lhdai@lnm.imech.ac.cn |
| 关键词 | Smooth-Muscle-Cells Focal Adhesions Stress Fibers Mechanosensory Function Extracellular-Matrix Orientation Response Integrin Ligands Mechanical Force Model Alignment |
| ISSN号 | 0006-3495 |
| 通讯作者 | Dai, LH (reprint author), Chinese Acad Sci, Inst Mech, LNM, State Key Lab Nonlinear Mech, Beijing 100080, Peoples R China. |
| 中文摘要 | This work is motivated by experimental observations that cells on stretched substrate exhibit different responses to static and dynamic loads. A model of focal adhesion that can consider the mechanics of stress fiber, adhesion bonds, and substrate was developed at the molecular level by treating the focal adhesion as an adhesion cluster. The stability of the cluster under dynamic load was studied by applying cyclic external strain on the substrate. We show that a threshold value of external strain amplitude exists beyond which the adhesion cluster disrupts quickly. In addition, our results show that the adhesion cluster is prone to losing stability under high-frequency loading, because the receptors and ligands cannot get enough contact time to form bonds due to the high-speed deformation of the substrate. At the same time, the viscoelastic stress fiber becomes rigid at high frequency, which leads to significant deformation of the bonds. Furthermore, we find that the stiffness and relaxation time of stress fibers play important roles in the stability of the adhesion cluster. The essence of this work is to connect the dynamics of the adhesion bonds (molecular level) with the cell's behavior during reorientation (cell level) through the mechanics of stress fiber. The predictions of the cluster model are consistent with experimental observations. |
| 类目[WOS] | Biophysics |
| 研究领域[WOS] | Biophysics |
| 关键词[WOS] | SMOOTH-MUSCLE-CELLS ; FOCAL ADHESIONS ; STRESS FIBERS ; MECHANOSENSORY FUNCTION ; EXTRACELLULAR-MATRIX ; ORIENTATION RESPONSE ; INTEGRIN LIGANDS ; MECHANICAL FORCE ; MODEL ; ALIGNMENT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000259503900045 |
| 公开日期 | 2009-08-03 ; 2009-09-14 |
| 源URL | [http://dspace.imech.ac.cn/handle/311007/25898]  |
| 专题 | 力学研究所_力学所知识产出(1956-2008) |
| 推荐引用方式 GB/T 7714 | Kong D,Ji BH,Dai LH. Stability Of Adhesion Clusters And Cell Reorientation Under Lateral Cyclic Tension[J]. Biophysical Journal,2008:4034-4044. |
| APA | 孔冬,季葆华,&戴兰宏.(2008).Stability Of Adhesion Clusters And Cell Reorientation Under Lateral Cyclic Tension.Biophysical Journal,4034-4044. |
| MLA | 孔冬,et al."Stability Of Adhesion Clusters And Cell Reorientation Under Lateral Cyclic Tension".Biophysical Journal (2008):4034-4044. |
入库方式： OAI收割
来源：力学研究所
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