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Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry

文献类型：期刊论文

作者Mu, Ying1,4; Zhou, Yang2,3; Wang, Yanfeng2,5; Li, Wei1; Zhou, Lina2; Lu, Xin2; Gao, Peng6; Gao, Mingyang1; Zhao, Yanhui4; Wang, Qi3
刊名JOURNAL OF PROTEOME RESEARCH
出版日期2019-05-01
卷号18期号:5页码:2175-2184
关键词non-small cell lung cancer metabolomics nonsmoking female gas chromatography-mass spectrometry biomarker
ISSN号1535-3893
DOI10.1021/acs.jproteome.9b00069
通讯作者Wang, Yanfu(wangyanfu2000@163.com) ; Xu, Guowang(xugw@dicp.ac.cn)
英文摘要The incidence of nonsmoking female patients with non-small cell lung cancer (NSCLC) has increased in recent decades; however, the pathogenesis of patients is unclear, and early diagnosis biomarkers are in urgent need. In this study, 136 nonsmoking female subjects (65 patients with NSCLC, 6 patients with benign lung tumors, and 65 healthy controls) were enrolled, and their metabolic profiling was investigated by using pseudotargeted gas chromatography mass spectrometry. A total of 56 annotated metabolites were found and verified to be significantly different in nonsmoking females with NSCLC compared with the control. The metabolic profiling was featured by disturbed energy metabolism, amino acid metabolism, oxidative stress, lipid metabolism, and so on. Cysteine, serine, and 1-monooleoylglycerol were defined as the biomarker panel for the diagnosis of NSCLC patients. 98.5 and 91.4% of subjects were correctly distinguished in the discovery and validation sets, respectively. The biomarker panel was also useful for the diagnosis of in situ malignancy patients, with an accuracy of 97.7 and 97.8% in the discovery and validation sets, respectively. The study provides a biomarker panel for the auxiliary diagnosis of nonsmoking females with NSCLC.
WOS关键词NEVER-SMOKERS ; POTENTIAL BIOMARKERS ; METABOLITE PROFILES ; PROSTATE-CANCER ; METABONOMICS ; GLUTATHIONE ; SIGNATURES ; DISCOVERY ; SURVIVAL ; ADENOCARCINOMA
资助项目Liaoning Provincial Natural Science Foundation of China[2012225020] ; Liaoning Provincial Natural Science Foundation of China[20180530107]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000467317700022
出版者AMER CHEMICAL SOC
资助机构Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China ; Liaoning Provincial Natural Science Foundation of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/165468]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Wang, Yanfu; Xu, Guowang
作者单位1.Dalian Med Univ, Affiliated Hosp 1, Dalian 116000, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
3.Dalian Med Univ, Affiliated Hosp 2, Dalian 116027, Peoples R China
4.Lib Liaoning Univ Tradit Chinese Med, Dalian Branch, Dalian 116600, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Dalian Sixth Peoples Hosp, Clin Lab, Dalian 116031, Peoples R China
推荐引用方式
GB/T 7714		 Mu, Ying,Zhou, Yang,Wang, Yanfeng,et al. Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry[J]. JOURNAL OF PROTEOME RESEARCH,2019,18(5):2175-2184.
APA Mu, Ying.,Zhou, Yang.,Wang, Yanfeng.,Li, Wei.,Zhou, Lina.,...&Xu, Guowang.(2019).Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry.JOURNAL OF PROTEOME RESEARCH,18(5),2175-2184.
MLA Mu, Ying,et al."Serum Metabolomics Study of Nonsmoking Female Patients with Non-Small Cell Lung Cancer Using Gas Chromatography-Mass Spectrometry".JOURNAL OF PROTEOME RESEARCH 18.5(2019):2175-2184.

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来源：大连化学物理研究所

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