Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro
文献类型：期刊论文
| 作者 | Dou, Ya-Kun1; Shang, Yue2; He, Xi-Wen1; Li, Wen-You1,3; Li, Yu-Hao2; Zhang, Yu-Kui1,4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2019-04-17 |
| 卷号 | 11期号:15页码:13954-13963 |
| 关键词 | silicon nanoparticle composite two-photon excitation fluorescence resonance energy transfer targeted fluorescence imaging photodynamic therapy in vitro |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.9b00288 |
| 通讯作者 | Li, Wen-You(wyli@nankai.edu.cn) ; Li, Yu-Hao(liyuhao@nankai.edu.cn) |
| 英文摘要 | Silicon nanoparticles (SiNPs), especially those emitting red fluorescence, have been widely applied in the field of bioimaging. However, harsh synthetic conditions and strong biological autofluorescence caused by short wavelength excitation restrict the further development of SiNPs in the field of biological applications. Here, we report a method for synthesizing a ruthenium-complex-functionalized two-photon excited red fluorescence silicon nanoparticle composite (SiNPs Ru) based on fluorescence resonance energy transfer under mild experimental conditions. In the prepared SiNPs Ru composite, silicon nanoparticles synthesized by atmospheric pressure microwave-assisted synthesis served as a fluorescence energy donor, which had two-photon fluorescence properties, and tris(4,4'-dicarboxylic acid-2,2-bipyridyl)ruthenium(II) dichloride (LRu) acted as a fluorescence energy acceptor, which could emit red fluorescence as well as had the ability to produce singlet-oxygen for photodynamic therapy. Therefore, the synthesized SiNPs Ru could emit red fluorescence by two-photon excitation based on fluorescence resonance energy transfer, which could effectively avoid the interference of biological autofluorescence. Fluorescence imaging tests in zebrafish and nude mice indicated that the as-prepared SiNPs Ru could act as a new kind of fluorescence probe for fluorescence imaging in vivo. By coupling folic acid (FA) to SiNPs Ru, the prepared composite (FA SiNPs Ru) could not only serve as a targeted two photon fluorescence imaging probe but also kill cancer cells via photodynamic therapy in vitro. |
| WOS关键词 | GRAPHENE QUANTUM DOTS ; CARBON DOTS ; ROOM-TEMPERATURE ; CONTRAST AGENTS ; PHOTOSENSITIZERS ; LUMINESCENCE ; CYTOTOXICITY ; SIZE |
| 资助项目 | National Natural Science Foundation of China[21775077] ; National Natural Science Foundation of China[21475069] ; National Natural Science Foundation of China[81671179] ; Tianjin Natural Science Foundation[16JCZDJC37200] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000465189000014 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Tianjin Natural Science Foundation ; Tianjin Natural Science Foundation |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/165504]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Li, Wen-You; Li, Yu-Hao |
| 作者单位 | 1.Nankai Univ, Tianjin Key Lab Biosensing & Mol Recognit, State Key Lab Med Chem Biol, Coll Chem,Res Ctr Analyt Sci, Tianjin 300071, Peoples R China 2.Nankai Univ, Key Lab Tumor Microenvironm & Neurovasc Regulat, Sch Med, Tianjin 300071, Peoples R China 3.Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dou, Ya-Kun,Shang, Yue,He, Xi-Wen,et al. Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(15):13954-13963. |
| APA | Dou, Ya-Kun,Shang, Yue,He, Xi-Wen,Li, Wen-You,Li, Yu-Hao,&Zhang, Yu-Kui.(2019).Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro.ACS APPLIED MATERIALS & INTERFACES,11(15),13954-13963. |
| MLA | Dou, Ya-Kun,et al."Preparation of a Ruthenium-Complex-Functionalized Two-Photon-Excited Red Fluorescence Silicon Nanoparticle Composite for Targeted Fluorescence Imaging and Photodynamic Therapy in Vitro".ACS APPLIED MATERIALS & INTERFACES 11.15(2019):13954-13963. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。