Catalytic Prenylation and Reverse Prenylation of Indoles with Isoprene: Regioselectivity Manipulation through Choice of Metal Hydride
文献类型：期刊论文
| 作者 | Zhao, Chao-Yang; Hu, Yan-Cheng; Ji, Ding-Wei; Zheng, Hao; Chen, Qing-An |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2019-04-08 |
| 卷号 | 58期号:16页码:5438-5442 |
| 关键词 | indoles isoprenes metal hydrides prenylation reverse prenylation |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.201901025 |
| 通讯作者 | Chen, Qing-An(qachen@dicp.ac.cn) |
| 英文摘要 | The basic industrial feedstock isoprene was employed as a building block to install prenyl and reverse-prenyl groups onto indoles. The regioselectivity can be manipulated by the choice of metal hydride. Reverse-prenylated indoles were attained with high selectivity when using Rh-H. By switching to a Pd-H catalyst, selectivity toward prenylated indoles was achieved. This regiodivergent method also features high atom economy without stoichiometric byproduct formation. |
| WOS关键词 | ATOM-EFFICIENT SYNTHESIS ; ALLYLIC ALKYLATION ; DEAROMATIZATION REACTION ; TRYPROSTATIN B ; ALLYLATION ; 1,3-DIENES ; RUTHENIUM ; DIENES ; ALCOHOLS ; HYDROAMINATION |
| 资助项目 | Dalian Institute of Chemical Physics ; National Natural Science Foundation of China[21702204] ; National Natural Science Foundation of China[21801239] ; Chinese Academy of Sciences |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000463975300048 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; Chinese Academy of Sciences |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/165606]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Qing-An |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Chao-Yang,Hu, Yan-Cheng,Ji, Ding-Wei,et al. Catalytic Prenylation and Reverse Prenylation of Indoles with Isoprene: Regioselectivity Manipulation through Choice of Metal Hydride[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(16):5438-5442. |
| APA | Zhao, Chao-Yang,Hu, Yan-Cheng,Ji, Ding-Wei,Zheng, Hao,&Chen, Qing-An.(2019).Catalytic Prenylation and Reverse Prenylation of Indoles with Isoprene: Regioselectivity Manipulation through Choice of Metal Hydride.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(16),5438-5442. |
| MLA | Zhao, Chao-Yang,et al."Catalytic Prenylation and Reverse Prenylation of Indoles with Isoprene: Regioselectivity Manipulation through Choice of Metal Hydride".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.16(2019):5438-5442. |
入库方式： OAI收割
来源：大连化学物理研究所
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