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Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines

文献类型：期刊论文

作者Sun, Lei2; Meng, Fan-Jie1,2; Shi, Lei1,2; Feng, Guang-Shou2; Zhou, Yong-Gui2
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2019-04-05
卷号84期号:7页码:4435-4442
ISSN号0022-3263
DOI10.1021/acs.joc.8b03128
通讯作者Shi, Lei(shileichem@dlut.edu.cn) ; Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要Chiral phosphoric acid-catalyzed transfer hydrogenation of 2-hydroxypyrimidines has been successfully realized using Hantzsch ester or dihydrophenanthridine as the hydrogen source, furnishing the chiral 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) with excellent yields and enantioselectivities of <= 99%. Notably, a novel kind of chiral DHPMs with an alkyl stereogenic center can be prepared through highly chemoselective transfer hydrogenation.
WOS关键词ASYMMETRIC HYDROGENATION ; BIGINELLI REACTIONS ; BRONSTED ACID ; EFFICIENT ; AGENT ; AMINE ; DEHYDROGENATION ; ACTIVATION ; RESOLUTION ; CATALYST
资助项目National Natural Science Foundation of China[21772195] ; National Natural Science Foundation of China[21532006] ; Strategic Priority Program of Chinese Academy of Sciences[XDB17020300]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000464250800067
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Strategic Priority Program of Chinese Academy of Sciences ; Strategic Priority Program of Chinese Academy of Sciences
源URL[http://cas-ir.dicp.ac.cn/handle/321008/165674]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Shi, Lei; Zhou, Yong-Gui
作者单位1.Dalian Univ Technol, Sch Chem, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Lei,Meng, Fan-Jie,Shi, Lei,et al. Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines[J]. JOURNAL OF ORGANIC CHEMISTRY,2019,84(7):4435-4442.
APA Sun, Lei,Meng, Fan-Jie,Shi, Lei,Feng, Guang-Shou,&Zhou, Yong-Gui.(2019).Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines.JOURNAL OF ORGANIC CHEMISTRY,84(7),4435-4442.
MLA Sun, Lei,et al."Enantioselective Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones through Organocatalytic Transfer Hydrogenation of 2-Hydroxypyrimidines".JOURNAL OF ORGANIC CHEMISTRY 84.7(2019):4435-4442.

入库方式： OAI收割

来源：大连化学物理研究所

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