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Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer

文献类型：期刊论文

作者Wang, Shuang2,3; Wang, Weimin2,3; Li, Hong1; Xing, Yuming1; Hou, Keyong3; Li, Haiyang3
刊名ANALYTICAL CHEMISTRY
出版日期2019-03-19
卷号91期号:6页码:3845-3851
ISSN号0003-2700
DOI10.1021/acs.analchem.8b04168
通讯作者Hou, Keyong(houky@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要Illegal drug smugglings and crimes have long been a global concern, and an apparatus which can identify drugs on-the-spot is urgently demanded by law enforcement. A thermal desorption acetone-assisted photoionization miniature ion trap mass spectrometer was developed for on-site and rapid identification of illegal drugs at checkpoints. Acetone was chosen for dopant-assisted photoionization, and the sensitivity of selected drugs was further enhanced with protonated analyte molecular ions [M + H](+). For example, the sensitivity of ephedrine was improved by as high as 22-fold. The mass discrimination effect, which was usually considered as a shortcoming of ion trap mass analyzer, was ingeniously utilized to eliminate the protonated acetone reagent ions and maximize the trapping efficiency of analyte ions in mass analyzer. Twenty-seven drugs were analyzed, and the limits of detection (LODs) of selected illegal drugs were at the nanogram level with analysis time of 2 s. Analyte/dopant ion peak intensity ratios in mass spectra could be used for quantitation to improve the quantitative analysis performance of miniature ion trap mass spectrometer equipped with a discontinuous atmospheric pressure interface (DAPI) with the prerequisite that dopant ions and analyte ions could be simultaneously and effectively trapped by the ion trap. The RSD of signal intensity was reduced from 25.3% to 8.5%, and the linear range was extended from 0.5-25 to 0.5-100 ng/mu L for methamphetamine. A temperature-resolved thermal desorption sampling strategy was developed and used to distinguish illegal drug components in plant-based drug samples and drinks containing illegal drugs.
WOS关键词ATMOSPHERIC-PRESSURE PHOTOIONIZATION ; MOBILITY SPECTROMETRY ; AMBIENT IONIZATION ; RAMAN-SPECTROSCOPY ; CROSS-SECTIONS ; CANNABINOIDS ; PERFORMANCE ; PEOPLE ; ABUSE
资助项目National Natural Science Foundation of China[21675155] ; National Key Research and Development Program of China[2016YFC0800902] ; DICP[DICP ZZBS201701]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000462098300014
出版者AMER CHEMICAL SOC
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; DICP ; DICP
源URL[http://cas-ir.dicp.ac.cn/handle/321008/165712]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Hou, Keyong; Li, Haiyang
作者单位1.Yunnan Police Officer Acad, 249 Jiaochang North Rd, Kunming 650223, Yunnan, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shuang,Wang, Weimin,Li, Hong,et al. Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer[J]. ANALYTICAL CHEMISTRY,2019,91(6):3845-3851.
APA Wang, Shuang,Wang, Weimin,Li, Hong,Xing, Yuming,Hou, Keyong,&Li, Haiyang.(2019).Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer.ANALYTICAL CHEMISTRY,91(6),3845-3851.
MLA Wang, Shuang,et al."Rapid On-Site Detection of Illegal Drugs in Complex Matrix by Thermal Desorption Acetone-Assisted Photoionization Miniature Ion Trap Mass Spectrometer".ANALYTICAL CHEMISTRY 91.6(2019):3845-3851.

入库方式： OAI收割

来源：大连化学物理研究所

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