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Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model

文献类型：期刊论文

作者Kovatcheva-Datchary, Petia5,7; Shoaie, Saeed1; Lee, Sunjae1; Wahlstrom, Annika7; Nookaew, Intawat2,6; Hallen, Anna7; Perkins, Rosie7; Nielsen, Jens2,3; Backhed, Fredrik4,7
刊名CELL REPORTS
出版日期2019-03-26
卷号26期号:13页码:3772-+
ISSN号2211-1247
DOI10.1016/j.celrep.2019.02.090
通讯作者Backhed, Fredrik(fredrik.backhed@wlab.gu.se)
英文摘要The gut microbiota can modulate human metabolism through interactions with macronutrients. However, microbiota-diet-host interactions are difficult to study because bacteria interact in complex food webs in concert with the host, and many of the bacteria are not yet characterized. To reduce the complexity, we colonize mice with a simplified intestinal microbiota (SIM) composed of ten sequenced strains isolated from the human gut with complementing pathways to metabolize dietary fibers. We feed the SIM mice one of three diets (chow [fiber rich], high-fat/high-sucrose, or zero-fat/high-sucrose diets [both low in fiber]) and investigate (1) how dietary fiber, saturated fat, and sucrose affect the abundance and transcriptome of the SIM community, (2) the effect of microbe-diet interactions on circulating metabolites, and (3) how microbiota-diet interactions affect host metabolism. Our SIM model can be used in future studies to help clarify how microbiota-diet interactions contribute to metabolic diseases.
WOS关键词BUTYRATE-PRODUCING BACTERIA ; HUMAN COLONIC MICROBIOTA ; GUT MICROBIOTA ; SP NOV. ; AKKERMANSIA-MUCINIPHILA ; GENE-EXPRESSION ; IDENTIFICATION ; FERMENTATION ; PROPOSAL ; FIBER
资助项目DuPont Young Professor Award ; Swedish Research Council ; IngaBritt and Arne Lundberg's Foundation ; Knut and Alice Wallenberg Foundation ; Novo Nordisk Foundation[NNF13OC008163] ; Leducq Foundation[17CVD01] ; Swedish government[17CVD01] ; county councils[ALFGBG-718101] ; European Research Council (ERC) Consolidator Grant[615362] ; CAS President's International Fellowship Initiative (PIFI)[2018PB0028] ; DICP Outstanding Postdoctoral Foundation[2017YB05] ; Engineering and Physical Sciences Research Council (EPSRC)[EP/S001301/1]
WOS研究方向Cell Biology
语种英语
WOS记录号WOS:000462490900026
出版者CELL PRESS
资助机构DuPont Young Professor Award ; DuPont Young Professor Award ; Swedish Research Council ; Swedish Research Council ; IngaBritt and Arne Lundberg's Foundation ; IngaBritt and Arne Lundberg's Foundation ; Knut and Alice Wallenberg Foundation ; Knut and Alice Wallenberg Foundation ; Novo Nordisk Foundation ; Novo Nordisk Foundation ; Leducq Foundation ; Leducq Foundation ; Swedish government ; Swedish government ; county councils ; county councils ; European Research Council (ERC) Consolidator Grant ; European Research Council (ERC) Consolidator Grant ; CAS President's International Fellowship Initiative (PIFI) ; CAS President's International Fellowship Initiative (PIFI) ; DICP Outstanding Postdoctoral Foundation ; DICP Outstanding Postdoctoral Foundation ; Engineering and Physical Sciences Research Council (EPSRC) ; Engineering and Physical Sciences Research Council (EPSRC) ; DuPont Young Professor Award ; DuPont Young Professor Award ; Swedish Research Council ; Swedish Research Council ; IngaBritt and Arne Lundberg's Foundation ; IngaBritt and Arne Lundberg's Foundation ; Knut and Alice Wallenberg Foundation ; Knut and Alice Wallenberg Foundation ; Novo Nordisk Foundation ; Novo Nordisk Foundation ; Leducq Foundation ; Leducq Foundation ; Swedish government ; Swedish government ; county councils ; county councils ; European Research Council (ERC) Consolidator Grant ; European Research Council (ERC) Consolidator Grant ; CAS President's International Fellowship Initiative (PIFI) ; CAS President's International Fellowship Initiative (PIFI) ; DICP Outstanding Postdoctoral Foundation ; DICP Outstanding Postdoctoral Foundation ; Engineering and Physical Sciences Research Council (EPSRC) ; Engineering and Physical Sciences Research Council (EPSRC) ; DuPont Young Professor Award ; DuPont Young Professor Award ; Swedish Research Council ; Swedish Research Council ; IngaBritt and Arne Lundberg's Foundation ; IngaBritt and Arne Lundberg's Foundation ; Knut and Alice Wallenberg Foundation ; Knut and Alice Wallenberg Foundation ; Novo Nordisk Foundation ; Novo Nordisk Foundation ; Leducq Foundation ; Leducq Foundation ; Swedish government ; Swedish government ; county councils ; county councils ; European Research Council (ERC) Consolidator Grant ; European Research Council (ERC) Consolidator Grant ; CAS President's International Fellowship Initiative (PIFI) ; CAS President's International Fellowship Initiative (PIFI) ; DICP Outstanding Postdoctoral Foundation ; DICP Outstanding Postdoctoral Foundation ; Engineering and Physical Sciences Research Council (EPSRC) ; Engineering and Physical Sciences Research Council (EPSRC) ; DuPont Young Professor Award ; DuPont Young Professor Award ; Swedish Research Council ; Swedish Research Council ; IngaBritt and Arne Lundberg's Foundation ; IngaBritt and Arne Lundberg's Foundation ; Knut and Alice Wallenberg Foundation ; Knut and Alice Wallenberg Foundation ; Novo Nordisk Foundation ; Novo Nordisk Foundation ; Leducq Foundation ; Leducq Foundation ; Swedish government ; Swedish government ; county councils ; county councils ; European Research Council (ERC) Consolidator Grant ; European Research Council (ERC) Consolidator Grant ; CAS President's International Fellowship Initiative (PIFI) ; CAS President's International Fellowship Initiative (PIFI) ; DICP Outstanding Postdoctoral Foundation ; DICP Outstanding Postdoctoral Foundation ; Engineering and Physical Sciences Research Council (EPSRC) ; Engineering and Physical Sciences Research Council (EPSRC)
源URL[http://cas-ir.dicp.ac.cn/handle/321008/165776]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Backhed, Fredrik
作者单位1.Kings Coll London, Ctr Host Microbiome Interact, Dent Inst, London SE1 9RT, England
2.Chalmers Univ Technol, Dept Biol & Biol Engn, S-41345 Gothenburg, Sweden
3.Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, DK-2800 Lyngby, Denmark
4.Univ Copenhagen, Fac Hlth Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Sect Metab Receptol & Enteroendocrinol, DK-2200 Copenhagen, Denmark
5.Chinese Acad Sci, Sci Res Ctr Translat Med, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
6.Univ Arkansas Med Sci, Coll Med, Dept Biomed Informat, Little Rock, AR 72205 USA
7.Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, S-41345 Gothenburg, Sweden
推荐引用方式
GB/T 7714		 Kovatcheva-Datchary, Petia,Shoaie, Saeed,Lee, Sunjae,et al. Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model[J]. CELL REPORTS,2019,26(13):3772-+.
APA Kovatcheva-Datchary, Petia.,Shoaie, Saeed.,Lee, Sunjae.,Wahlstrom, Annika.,Nookaew, Intawat.,...&Backhed, Fredrik.(2019).Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model.CELL REPORTS,26(13),3772-+.
MLA Kovatcheva-Datchary, Petia,et al."Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model".CELL REPORTS 26.13(2019):3772-+.

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来源：大连化学物理研究所

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