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Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells

文献类型：期刊论文

作者Li, Dangsheng6; Cui, Bai1,2; Luo, Yuanyuan1; Tian, Pengfei1; Peng, Fei1; Lu, Jinxin1,3; Yang, Yongliang4; Su, Qitong1; Liu, Bing1; Yu, Jiachuan1
刊名JOURNAL OF CLINICAL INVESTIGATION
出版日期2019-03-01
卷号129期号:3页码:1030-1046
ISSN号0021-9738
DOI10.1172/JCI121685
通讯作者Liu, Quentin(liuq9@mail.sysu.edu.cn)
英文摘要Chronic stress triggers activation of the sympathetic nervous system and drives malignancy. Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring. Chronic stress-induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC. The SLUG promoter was then activated by MYC, which promoted development of breast cancer stem-like traits. Using a drug screen that targeted LDHA, we found that a chronic stress-induced cancer stem-like phenotype could be reversed by vitamin C. These findings demonstrated the critical importance of psychological factors in promoting stem-like properties in breast cancer cells. Thus, the LDHA-lowering agent vitamin C can be a potential approach for combating stress-associated breast cancer.
WOS关键词SUPPRESSES TUMOR-GROWTH ; THERAPEUTIC TARGET ; HEMATOPOIETIC STEM ; PROTEIN-KINASE ; LACTIC-ACID ; C-MYC ; GLYCOLYSIS ; METASTASIS ; INVASION ; OXAMATE
资助项目National Natural Science Foundation of China[81820108024] ; National Natural Science Foundation of China[81630005] ; National Natural Science Foundation of China[81573025] ; National Natural Science Foundation of China[81703091] ; Science and Technology Planning Project of Guangzhou[201604020163] ; Dalian High-level Talent Innovation Program[2016RD12] ; Medical Research Council (MRC)[MR/N012097/1] ; Cancer Research UK (CRUK)[C37/A12011] ; Cancer Research UK (CRUK)[C37/A18784] ; Breast Cancer Now[2012MayPR070] ; Breast Cancer Now[2012NovPhD016] ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
WOS研究方向Research & Experimental Medicine
语种英语
出版者AMER SOC CLINICAL INVESTIGATION INC
WOS记录号WOS:000460125800017
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Science and Technology Planning Project of Guangzhou ; Science and Technology Planning Project of Guangzhou ; Dalian High-level Talent Innovation Program ; Dalian High-level Talent Innovation Program ; Medical Research Council (MRC) ; Medical Research Council (MRC) ; Cancer Research UK (CRUK) ; Cancer Research UK (CRUK) ; Breast Cancer Now ; Breast Cancer Now ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; CRUK Imperial Centre, Imperial Experimental Cancer Medicine Centre (ECMC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC) ; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre (BRC)
源URL[http://cas-ir.dicp.ac.cn/handle/321008/165838]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Liu, Quentin
作者单位1.Dalian Med Univ, Inst Canc Stem Cell, 9 Western Sect,Lvshun South St, Dalian 116044, Liaoning, Peoples R China
2.Sun Yat Sen Univ, Canc Ctr, State Key Lab Oncol South China, Guangzhou, Guangdong, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
4.Dalian Univ Technol, Sch Life Sci & Biotechnol, Ctr Mol Med, Dalian, Peoples R China
5.Dalian Med Univ, Affiliated Hosp 1, Dept Oncol, Dalian, Peoples R China
6.Chinese Acad Sci, Shanghai Informat Ctr Life Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China
7.Beijing Inst Life, Natl Ctr Prot Sci, State Key Lab Prote, Beijing, Peoples R China
8.Univ Kentucky, Coll Med, Markey Canc Ctr, Dept Mol & Cellular Biochem, Lexington, KY USA
9.Fudan Univ, Shanghai Canc Ctr, Shanghai, Peoples R China
10.Fudan Univ, Inst Biomed Sci, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Li, Dangsheng,Cui, Bai,Luo, Yuanyuan,et al. Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells[J]. JOURNAL OF CLINICAL INVESTIGATION,2019,129(3):1030-1046.
APA Li, Dangsheng.,Cui, Bai.,Luo, Yuanyuan.,Tian, Pengfei.,Peng, Fei.,...&Liu, Quentin.(2019).Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells.JOURNAL OF CLINICAL INVESTIGATION,129(3),1030-1046.
MLA Li, Dangsheng,et al."Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells".JOURNAL OF CLINICAL INVESTIGATION 129.3(2019):1030-1046.

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