Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry
文献类型：期刊论文
| 作者 | Jin, Jing1; Tan, Dongqin1,2; Wang, Longxing1; He, Xiaolin3; Guo, Cuicui1,2; Dhanjai1; Lu, Xianbo1; Chen, Jiping1 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2019-03-01 |
| 卷号 | 42期号:5页码:991-998 |
| 关键词 | bisphenol derivatization high-performance liquid chromatography serum tandem mass spectrometry |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.201800847 |
| 通讯作者 | Chen, Jiping(chenjp@dicp.ac.cn) |
| 英文摘要 | Due to regulation of the use of bisphenol A, several analogs serving as bisphenol A replacements have drawn substantial attention for their adverse health effects. To investigate their occurrence in humans and identify possible pollution sources, it is necessary to develop a sensitive method for total bisphenols detection. Thus, a method based on enzymolysis and liquid-liquid extraction followed by molecularly imprinted polymer solid-phase extraction and pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry was proposed. The developed method exhibited superior selectivity and sensitivity. The matrix effect can be eliminated to a great extent. The method detection limits for eight bisphenols were 0.05 similar to 0.19 ng/mL. Satisfactory recoveries (71 similar to 119%) were obtained by spiking bovine serum at three levels (0.8, 8 and, 20 ng/mL). The method was successfully applied to determine total bisphenols in the serum samples of children. Bisphenol A, bisphenol F, bisphenol S, bisphenol B and bisphenol F were detected with concentrations from below the method detection limit to 1.65, 0.45, 0.79, 2.04 and 0.17 ng/mL, respectively. These results indicate that bisphenol A remains the major pollutant among the studied bisphenols in children, whereas threats from bisphenol A analogs should also be monitored. |
| WOS关键词 | ENDOCRINE DISRUPTING CHEMICALS ; HUMAN PLASMA ; HUMAN URINE ; EXPOSURE ; CHLORIDE ; BLOOD ; MILK |
| 资助项目 | National Natural Science Foundation of China[21677143] ; National Natural Science Foundation of China[21475130] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000461674900004 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/165916]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Chen, Jiping |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Dalian Med Univ, Hosp 2, Dalian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Jing,Tan, Dongqin,Wang, Longxing,et al. Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry[J]. JOURNAL OF SEPARATION SCIENCE,2019,42(5):991-998. |
| APA | Jin, Jing.,Tan, Dongqin.,Wang, Longxing.,He, Xiaolin.,Guo, Cuicui.,...&Chen, Jiping.(2019).Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry.JOURNAL OF SEPARATION SCIENCE,42(5),991-998. |
| MLA | Jin, Jing,et al."Quantification of bisphenol A and its selected analogs in serum using pre-column derivatization with high-performance liquid chromatography and tandem mass spectrometry".JOURNAL OF SEPARATION SCIENCE 42.5(2019):991-998. |
入库方式： OAI收割
来源：大连化学物理研究所
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