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Rapid discrimination between red and white ginseng based on unique mass-spectrometric features

文献类型：期刊论文

作者Zhang, Xiaozhe2; Zhao, Qiang1,2; Zhao, Nan2; Ye, Xueting1,2; Yang, Yiren1,2; He, Meixi1,2; Gao, Huiyuan1
刊名JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
出版日期2019-02-05
卷号164页码:202-210
关键词UHPLC-Q-TOF-MS Red ginseng Robust biomarker Nitrogen-containing compound Support vector machine Artificial neural network
ISSN号0731-7085
DOI10.1016/j.jpba.2018.10.007
通讯作者Gao, Huiyuan(sypugaohy@163.com) ; Zhang, Xiaozhe(zhangxz@dicp.ac.cn)
英文摘要Red ginseng (RG) and white ginseng (WG), two processed products of Panax ginseng C. A. Meyer, are in high demand due to their unique features. In this study, some of these unique features were identified and confirmed as biomarkers of RG by using ultra-high-performance liquid chromatography-mass spectrometry, data mining, support vector machine, and artificial neural network. Principal component analysis showed clear separation between the RG and WG extracts, indicating the presence of potential discriminators. In addition, 20 features that are dominant in RG were found by data mining. Samples of Panax quinquefolium (PQ) and Panax notoginseng (PN), close relatives of Panax ginseng C.A.Meyer, were investigated and it was found that 17 features which were absent in PQ and PN samples, were present in RG and WG. Five of these markers were identified as nitrogen-containing compounds that have not been previously reported. Finally, we found that RG can be identified among different ginseng medicinal herbs including RG, WG, PQ and PN samples, by loading four feature markers corresponding to nitrogen-containing compounds into a discriminating model, based on a support vector machine or an artificial neural network. Thus, this study provides an efficient tool to identify RG during pharmacological research. (C) 2018 Elsevier B.V. All rights reserved.
WOS关键词PANAX-GINSENG ; METABOLOMIC APPROACH ; GINSENOSIDES ; DIFFERENTIATION ; QUANTIFICATION ; CHROMATOGRAPHY ; DISCOVERY ; PRODUCTS
资助项目Ministry of Science and Technology of the People's Republic of China[2015DFG42460] ; National Science Foundation[21475128] ; Bureau of International Cooperation Chinese Academy of Sciences[121421KYSB20160006] ; City Administration of Foreign Experts Affairs Dalian
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000456900700025
出版者ELSEVIER SCIENCE BV
资助机构Ministry of Science and Technology of the People's Republic of China ; Ministry of Science and Technology of the People's Republic of China ; National Science Foundation ; National Science Foundation ; Bureau of International Cooperation Chinese Academy of Sciences ; Bureau of International Cooperation Chinese Academy of Sciences ; City Administration of Foreign Experts Affairs Dalian ; City Administration of Foreign Experts Affairs Dalian ; Ministry of Science and Technology of the People's Republic of China ; Ministry of Science and Technology of the People's Republic of China ; National Science Foundation ; National Science Foundation ; Bureau of International Cooperation Chinese Academy of Sciences ; Bureau of International Cooperation Chinese Academy of Sciences ; City Administration of Foreign Experts Affairs Dalian ; City Administration of Foreign Experts Affairs Dalian ; Ministry of Science and Technology of the People's Republic of China ; Ministry of Science and Technology of the People's Republic of China ; National Science Foundation ; National Science Foundation ; Bureau of International Cooperation Chinese Academy of Sciences ; Bureau of International Cooperation Chinese Academy of Sciences ; City Administration of Foreign Experts Affairs Dalian ; City Administration of Foreign Experts Affairs Dalian ; Ministry of Science and Technology of the People's Republic of China ; Ministry of Science and Technology of the People's Republic of China ; National Science Foundation ; National Science Foundation ; Bureau of International Cooperation Chinese Academy of Sciences ; Bureau of International Cooperation Chinese Academy of Sciences ; City Administration of Foreign Experts Affairs Dalian ; City Administration of Foreign Experts Affairs Dalian
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166232]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Zhang, Xiaozhe; Gao, Huiyuan
作者单位1.Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Xiaozhe,Zhao, Qiang,Zhao, Nan,et al. Rapid discrimination between red and white ginseng based on unique mass-spectrometric features[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2019,164:202-210.
APA Zhang, Xiaozhe.,Zhao, Qiang.,Zhao, Nan.,Ye, Xueting.,Yang, Yiren.,...&Gao, Huiyuan.(2019).Rapid discrimination between red and white ginseng based on unique mass-spectrometric features.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,164,202-210.
MLA Zhang, Xiaozhe,et al."Rapid discrimination between red and white ginseng based on unique mass-spectrometric features".JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 164(2019):202-210.

入库方式： OAI收割

来源：大连化学物理研究所

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