A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier
文献类型：期刊论文
| 作者 | Zhang, Min2; Chen, Wenwen2,4; Qin, Jianhua1,2,3,4; Yin, Fangchao2,4; Zhu, Yujuan2,4; Yu, Hao2 |
| 刊名 | TOXICOLOGY IN VITRO
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 54页码:105-113 |
| 关键词 | 3D human placenta-on-a-chip Nanoparticle exposure Organ-on-a -chip |
| ISSN号 | 0887-2333 |
| DOI | 10.1016/j.tiv.2018.08.014 |
| 通讯作者 | Qin, Jianhua(jhqin@dicp.ac.cn) |
| 英文摘要 | With the commercialization of nanomaterials, environmental exposure to nanoparticles (NPs) has raised great concerns due to the long-term effects to human body, particularly to pregnant women. Previous studies found that NPs had an adverse impact on placenta in mice, but care must be taken when extrapolating the results to human pregnancy in consideration of the great difference between species. Here, we proposed a micro engineered 3D placental barrier-on-a-chip microdevice and further explored complicated placental responses to NPs exposure in vitro. The microdevice recreated near-physiological 3D microenvironment and dynamic conditions in fetal maternal circulation combined with the extracellular matrix and flow. With the exposure to titanium dioxide nanoparticles (TiO2-NPs), a common nanomaterial, a series of placental responses were investigated, including oxidative stress, cell apoptosis, barrier permeability, and maternal immune cell behavior. By contrast to oxidative stress and cell apoptosis, placental barrier integrity and maternal immune cells were greatly influenced even with low concentrated NPs, suggesting the potential damages triggered by NPs in our daily life. Collectively, this in vitro experimental model of human placenta provides a simple platform to study environmental exposure to NPs, and might be potential for a wide range of applications in biological study, disease treatment and drug assessment. |
| WOS关键词 | INFLAMMATION |
| 资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB0305] ; International Science & Technology Cooperation Program of China[2015DFA00740] ; Key Program of the Chinese Academy of Sciences[KFZD-SW-213] ; National Key R&D Program of China[2017YFB0405400] ; National Nature Science Foundation of China[91543121] ; National Nature Science Foundation of China[81573394] ; National Nature Science Foundation of China[31671038] ; National Nature Science Foundation of China[81603075] ; National Nature Science Foundation of China[21607151] ; Innovation Program of Science and Research from the DICP, CAS[DICP TMSR201601] |
| WOS研究方向 | Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000454467300012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; International Science & Technology Cooperation Program of China ; International Science & Technology Cooperation Program of China ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/166304]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Qin, Jianhua |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Div Biotechnol, Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100864, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Min,Chen, Wenwen,Qin, Jianhua,et al. A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier[J]. TOXICOLOGY IN VITRO,2019,54:105-113. |
| APA | Zhang, Min,Chen, Wenwen,Qin, Jianhua,Yin, Fangchao,Zhu, Yujuan,&Yu, Hao.(2019).A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier.TOXICOLOGY IN VITRO,54,105-113. |
| MLA | Zhang, Min,et al."A 3D human placenta-on-a-chip model to probe nanoparticle exposure at the placental barrier".TOXICOLOGY IN VITRO 54(2019):105-113. |
入库方式： OAI收割
来源：大连化学物理研究所
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