Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile
文献类型：期刊论文
| 作者 | Gu, Zheng2; Wu, Bo1; Jiang, Guo-Fang2; Zhou, Yong-Gui1 |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2018-12-01 |
| 卷号 | 36期号:12页码:1130-1134 |
| 关键词 | 1,4-dihydropyridines cycloaddition azadienes tandem reactions organocatalysis asymmetric synthesis |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201800330 |
| 通讯作者 | Zhou, Yong-Gui(ygzhou@dicp.ac.cn) |
| 英文摘要 | An efficient bifunctional squaramide-catalyzed Michael addition/cyclization of azadienes with malononitrile has been successfully developed, providing a facile access to chiral benzofuran-fused 1,4-dihydropyridines with excellent yields, wide substrate scope and up to 99% ee. Additionally, this formal [4+2] cycloaddition can be performed in gram scale without noticeable loss of yield and enantioselectivity. |
| WOS关键词 | ORTHO-QUINONE METHIDES ; ENANTIOSELECTIVE CONJUGATE ADDITIONS ; ORGANOCATALYTIC ASYMMETRIC-SYNTHESIS ; DIELS-ALDER REACTION ; K+ CHANNEL OPENER ; IN-SITU ; ALPHA,BETA-UNSATURATED IMIDES ; KINETIC RESOLUTION ; MANNICH REACTION ; TRANSFER HYDROGENATION |
| 资助项目 | National Natural Science Foundation of China[21532006] ; Dalian Bureau of Science and Technology[2016RD07] ; Dalian Institute of Chemical Physics[ZZBS201602] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000450017200002 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/166690]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Zhou, Yong-Gui |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Liaoning, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,et al. Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile[J]. CHINESE JOURNAL OF CHEMISTRY,2018,36(12):1130-1134. |
| APA | Gu, Zheng,Wu, Bo,Jiang, Guo-Fang,&Zhou, Yong-Gui.(2018).Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile.CHINESE JOURNAL OF CHEMISTRY,36(12),1130-1134. |
| MLA | Gu, Zheng,et al."Synthesis of Benzofuran-fused 1,4-Dihydropyridines via Bifunctional Squaramide-catalyzed Formal [4+2] Cycloaddition of Azadienes with Malononitrile".CHINESE JOURNAL OF CHEMISTRY 36.12(2018):1130-1134. |
入库方式： OAI收割
来源：大连化学物理研究所
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