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[4+1] Cycloaddition of Enaminothiones and Aldehyde N-Tosylhydrazones Toward 3-Aminothiophenes

文献类型：期刊论文

作者Liu, Zhuqing1,3; Wu, Ping1,3; He, Yuan1,3; Yang, Ting3; Yu, Zhengkun2,3
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2018-11-16
卷号360期号:22页码:4381-4392
关键词thiophenes enaminothiones hydrazones cycloaddition 3-aminothiophenes
ISSN号1615-4150
DOI10.1002/adsc.201801028
通讯作者Yu, Zhengkun(zkyu@dicp.ac.cn)
英文摘要An efficient protocol toward trisubstituted 3-aminothiophenes has been developed through a [4+1] cycloaddition of enaminothiones and aldehyde N-tosylhydrazones under transition-metal-free conditions. 3-Aminothiophene derivatives as well as their chiral analogs were obtained in good to excellent yields. Direct interaction of the enaminothiones with the diazo compounds of alpha-carbonyl or ester group-functionalized aldehydes also efficiently afforded the same type of 3-aminothiophenes. The diversity of the synthetic methodology has been demonstrated by the broad substrate scopes and excellent chemoselectivity in cleavage of the C-S, C-O, and C-N bonds in enaminothiones.
WOS关键词ONE-POT SYNTHESIS ; KETENE N,S-ACETALS ; THIOBENZOYLKETENE S,N-ACETALS ; THIOAROYLKETENE S,N-ACETALS ; MEDICINAL CHEMISTRY ; EFFICIENT SYNTHESIS ; DIAZO-COMPOUNDS ; DOMINO REACTION ; GENERAL-METHOD ; THIOPHENES
资助项目National Natural Science Foundation of China[21871253] ; National Natural Science Foundation of China[21472185] ; National Basic Research Program of China[2015CB856600]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000450364400015
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Basic Research Program of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166706]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Yu, Zhengkun
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, 354 Fenglin Rd, Shanghai 200032, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, 457 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Zhuqing,Wu, Ping,He, Yuan,et al. [4+1] Cycloaddition of Enaminothiones and Aldehyde N-Tosylhydrazones Toward 3-Aminothiophenes[J]. ADVANCED SYNTHESIS & CATALYSIS,2018,360(22):4381-4392.
APA Liu, Zhuqing,Wu, Ping,He, Yuan,Yang, Ting,&Yu, Zhengkun.(2018).[4+1] Cycloaddition of Enaminothiones and Aldehyde N-Tosylhydrazones Toward 3-Aminothiophenes.ADVANCED SYNTHESIS & CATALYSIS,360(22),4381-4392.
MLA Liu, Zhuqing,et al."[4+1] Cycloaddition of Enaminothiones and Aldehyde N-Tosylhydrazones Toward 3-Aminothiophenes".ADVANCED SYNTHESIS & CATALYSIS 360.22(2018):4381-4392.

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来源：大连化学物理研究所

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