中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Measurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal Microfluidic Device

文献类型:期刊论文

作者Lin, Bingcheng2,4; Gao, Zhigang2; Chen, Zongzheng3; Deng, Jiu2; Li, Xiaorui2; Qu, Yueyang2; Xu, Lingling2; Luo, Yong2; Lu, Yao4; Liu, Tingjiao1
刊名MICROMACHINES
出版日期2018-09-01
卷号9期号:9页码:10
ISSN号2072-666X
关键词centrifugal microfluidic device CEA detection density medium fluorescent chemiluminescence
DOI10.3390/mi9090470
通讯作者Luo, Yong(yluo@dlut.edu.cn) ; Zhao, Weijie(zyzhao@dlut.edu.cn)
英文摘要Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker used in clinical applications. The primarily clinical method for measuring CEA is based on chemiluminescence in serum during enzyme-linked immunosorbent assays (ELISA) in 96-well plates. However, this multi-step process requires large and expensive instruments, and takes a long time. In this study, a high-throughput centrifugal microfluidic device was developed for detecting CEA in serum without the need for cumbersome washing steps normally used in immunoreactions. This centrifugal microdevice contains 14 identical pencil-like units, and the CEA molecules are separated from the bulk serum for subsequent immunofluorescence detection using density gradient centrifugation in each unit simultaneously. To determine the optimal conditions for CEA detection in serum, the effects of the density of the medium, rotation speed, and spin duration were investigated. The measured values from 34 clinical serum samples using this high-throughput centrifugal microfluidic device showed good agreement with the known values (average relative error = 9.22%). These results indicate that the high-throughput centrifugal microfluidic device could provide an alternative approach for replacing the classical method for CEA detection in clinical serum samples.
WOS关键词CARCINO EMBRYONIC ANTIGEN ; BREAST-CANCER PATIENTS ; COLORECTAL-CANCER ; IMMUNOASSAY ; CEA ; ADENOCARCINOMA ; CHEMOTHERAPY ; CA-19-9
资助项目National Natural Science Foundation of China[21675017] ; National Key Research and Development Program of China[SQ2017YFC170204-001]
WOS研究方向Science & Technology - Other Topics ; Instruments & Instrumentation
语种英语
出版者MDPI
WOS记录号WOS:000448399300052
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166774]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Luo, Yong; Zhao, Weijie
作者单位1.Dalian Med Univ, Coll Stomatol, Dalian 116024, Peoples R China
2.Dalian Univ Technol, Sch Pharmaceut Sci & Technol, Dalian 116024, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Guangdong, Peoples R China
4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Lin, Bingcheng,Gao, Zhigang,Chen, Zongzheng,et al. Measurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal Microfluidic Device[J]. MICROMACHINES,2018,9(9):10.
APA Lin, Bingcheng.,Gao, Zhigang.,Chen, Zongzheng.,Deng, Jiu.,Li, Xiaorui.,...&Zhao, Weijie.(2018).Measurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal Microfluidic Device.MICROMACHINES,9(9),10.
MLA Lin, Bingcheng,et al."Measurement of Carcinoembryonic Antigen in Clinical Serum Samples Using a Centrifugal Microfluidic Device".MICROMACHINES 9.9(2018):10.

入库方式: OAI收割

来源:大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。