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Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles

文献类型：期刊论文

作者Zhou, Yong-Gui2,3; Yu, Chang-Bin2; Wang, Jie1,2
刊名ORGANIC CHEMISTRY FRONTIERS
出版日期2018-10-07
卷号5期号:19页码:2805-2809
ISSN号2052-4129
DOI10.1039/c8qo00710a
通讯作者Zhou, Yong-Gui(ygzhou@dicp.ac.cn)
英文摘要A concise and enantioselective procedure for the synthesis of optically active indolines has been developed through intramolecular condensation, deprotection and palladium-catalyzed asymmetric hydrogenation in a one-pot process with up to 96% ee. A strong BrOnsted acid played an important role in both the formation of indoles and asymmetric hydrogenation process. This strategy could be scaled-up with excellent reactivity and enantioselectivity.
WOS关键词HIGHLY ENANTIOSELECTIVE SYNTHESIS ; OXIDATIVE TANDEM CYCLIZATION ; REDUCTIVE AMINATION ; HETEROAROMATIC-COMPOUNDS ; 2,3-DISUBSTITUTED INDOLINES ; KINETIC RESOLUTION ; BRONSTED ACIDS ; ARYL KETONES ; ALKALOIDS ; CATALYSTS
资助项目National Natural Science Foundation of China[21532006] ; National Natural Science Foundation of China[21690074] ; Dalian Bureau of Science and Technology[2016RD07] ; Strategic Priority Program of the Chinese Academy of Sciences[XDB17020300]
WOS研究方向Chemistry
语种英语
出版者ROYAL SOC CHEMISTRY
WOS记录号WOS:000447950500005
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Bureau of Science and Technology ; Dalian Bureau of Science and Technology ; Strategic Priority Program of the Chinese Academy of Sciences ; Strategic Priority Program of the Chinese Academy of Sciences
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166800]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Zhou, Yong-Gui
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China
3.Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Yong-Gui,Yu, Chang-Bin,Wang, Jie. Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles[J]. ORGANIC CHEMISTRY FRONTIERS,2018,5(19):2805-2809.
APA Zhou, Yong-Gui,Yu, Chang-Bin,&Wang, Jie.(2018).Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles.ORGANIC CHEMISTRY FRONTIERS,5(19),2805-2809.
MLA Zhou, Yong-Gui,et al."Facile synthesis of chiral indolines through asymmetric hydrogenation of in situ generated indoles".ORGANIC CHEMISTRY FRONTIERS 5.19(2018):2805-2809.

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来源：大连化学物理研究所

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