Current and future perspectives of functional metabolomics in disease studies-A review
文献类型：期刊论文
| 作者 | Xu, Guowang1,2; Yan, Min1,2,3 |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2018-12-11 |
| 卷号 | 1037页码:41-54 |
| ISSN号 | 0003-2670 |
| 关键词 | Functional metabolomics Metabolomics Biological platform Cell metabolism Mass spectrometry |
| DOI | 10.1016/j.aca.2018.04.006 |
| 通讯作者 | Xu, Guowang(xugw@dicp.ac.cn) |
| 英文摘要 | Functional metabolomics is a new concept, which studies the functions of metabolites and related enzymes focused on metabolomics. It overcomes the shortcomings of traditional discovery metabolomics of mainly relying on literatures for biological interpretation. Functional metabolomics has many advantages. Firstly, the functional roles of metabolites and related metabolic enzymes are focused. Secondly, the in vivo and in vitro experiments are conducted to validate the metabolomics findings, therefore, increasing the reliability of metabolomics study and producing the new knowledge. Thirdly, functional metabolomics can be used by biologists to investigate functions of metabolites, and related genes and proteins. In this review, we summarize the analytical, biological and clinical platforms used in functional metabolomics studies. Recent progresses of functional metabolomics in cancer, metabolic diseases and biological phenotyping are reviewed, and future development is also predicted. Because of the tremendous advantages of functional metabolomics, it will have a bright future. (c) 2018 Elsevier B.V. All rights reserved. |
| WOS关键词 | CHROMATOGRAPHY-MASS-SPECTROMETRY ; CHAIN AMINO-ACIDS ; METABOLITE IDENTIFICATION APPLICATION ; ISOTOPE RESOLVED METABOLOMICS ; GC/MS-BASED METABOLOMICS ; RATIO OUTLIER ANALYSIS ; NMR-BASED METABOLOMICS ; LABELING LC-MS ; LIQUID-CHROMATOGRAPHY ; TARGETED METABOLOMICS |
| 资助项目 | National Key Research and Development Program of China[2017YFC0906900] ; National Key Research and Development Program of China[2016YFC0903302] ; National Natural Science Foundation of China[81472374] ; National Natural Science Foundation of China[21435006] ; innovation program of science and research from the DICP, CAS[DICP TMSR201601] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000446225000005 |
| 资助机构 | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/166838]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Sci Res Ctr Translat Med, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Guowang,Yan, Min. Current and future perspectives of functional metabolomics in disease studies-A review[J]. ANALYTICA CHIMICA ACTA,2018,1037:41-54. |
| APA | Xu, Guowang,&Yan, Min.(2018).Current and future perspectives of functional metabolomics in disease studies-A review.ANALYTICA CHIMICA ACTA,1037,41-54. |
| MLA | Xu, Guowang,et al."Current and future perspectives of functional metabolomics in disease studies-A review".ANALYTICA CHIMICA ACTA 1037(2018):41-54. |
入库方式： OAI收割
来源：大连化学物理研究所
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