Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review
文献类型：期刊论文
| 作者 | Liu, Xinyu; Xu, Guowang |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2018-12-11 |
| 卷号 | 1037页码:3-12 |
| 关键词 | Mitochondria Metabolomics Lipidomics Mass spectrometry Metabolic profiling |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2017.11.080 |
| 通讯作者 | Xu, Guowang(xugw@dicp.ac.cn) |
| 英文摘要 | Metabolomics and lipidomics generally targets a huge number of intermediate and end products of cellular metabolism in body fluids, tissues, and cells etc. At present, mass spectrometry (MS) based metabolic or lipid profiling of routine biological specimens including the whole cells, tissues, plasma, serum and urine etc., can cover hundreds of metabolites or lipid species in one analysis, which has qualified deep elucidation of global metabolic and lipid networks. Mitochondria are important intracellular organelles and many critical biochemical reactions occur here, they provide building block for new cells, control redox balance, participate in apoptosis and behave as a signalling platform. Evidence suggests high prevalence of mitochondrial dysfunction occurs in a variety of cancers and other diseases, thus there is an urgent demand for investigating and clarifying mitochondrial metabolic and lipid alterations induced by diseases. Nevertheless, mitochondria contribute a small fraction to cellular contents, profiling of whole cell is probably unsuitable for monitoring alterations in mitochondria. Therefore, metabolomics and lipidomics analyses specially for mitochondria are necessary to understand disturbed metabolic and lipid pathways induced by environment and diseases. However, methods for comprehensively profiling metabolites and lipids in mitochondria have been limited at present. This review summarizes the current states and progress of MS-based mitochondrial metabolomics and lipidomics study. Details of mitochondrial isolation procedure, analytical methods and their applications are described. The challenges and opportunities are also given. (c) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | SOLID-PHASE MICROEXTRACTION ; RAT-LIVER MITOCHONDRIA ; HEPATOCELLULAR-CARCINOMA ; TARGETED METABOLOMICS ; BRAIN MITOCHONDRIA ; SHOTGUN LIPIDOMICS ; BIOLOGICAL SAMPLES ; POTENTIAL BIOMARKERS ; FUNCTIONAL GENOMICS ; INTACT MITOCHONDRIA |
| 资助项目 | National Key Research and Development Program of China[2017YFC0906900] ; National Key Research and Development Program of China[2016YFC0903302] ; National Natural Science Foundation of China[21705147] ; National Natural Science Foundation of China[21435006] ; innovation program of science and research from the DICP, CAS[DICP TMSR201601] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000446225000002 |
| 出版者 | ELSEVIER SCIENCE BV |
| 资助机构 | National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; innovation program of science and research from the DICP, CAS ; innovation program of science and research from the DICP, CAS |
| 源URL | [http://cas-ir.dicp.ac.cn/handle/321008/166876]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 通讯作者 | Xu, Guowang |
| 作者单位 | Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Xinyu,Xu, Guowang. Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review[J]. ANALYTICA CHIMICA ACTA,2018,1037:3-12. |
| APA | Liu, Xinyu,&Xu, Guowang.(2018).Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review.ANALYTICA CHIMICA ACTA,1037,3-12. |
| MLA | Liu, Xinyu,et al."Recent advances in using mass spectrometry for mitochondrial metabolomics and lipidomics - A review".ANALYTICA CHIMICA ACTA 1037(2018):3-12. |
入库方式： OAI收割
来源：大连化学物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。