中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 大连化学物理研究所
  3. 中国科学院大连化学物理研究所
LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling

文献类型：期刊论文

作者Ju, Huai-qiang3; Sang, Ling-jie2; Liu, Guang-ping2,11; Tian, Tian3; Ma, Guo-lin8; Lu, Yun-xin3; Liu, Ze-xian3; Pan, Ruo-lang2; Li, Rui-hua2; Piao, Hai-long6
刊名MOLECULAR CELL
出版日期2018-10-04
卷号72期号:1页码:71-+
ISSN号1097-2765
DOI10.1016/j.molcel.2018.08.014
通讯作者Lin, Aifu(linaifu@zju.edu.cn)
英文摘要Cancer cells entail metabolic adaptation and microenvironmental remodeling to survive and progress. Both calcium (Ca2+) flux and Ca2+-dependent signaling play a crucial role in this process, although the underlying mechanism has yet to be elucidated. Through RNA screening, we identified one long noncoding RNA (lncRNA) named CamK-A (lncRNA for calcium-dependent kinase activation) in tumorigenesis. CamK-A is highly expressed in multiple human cancers and involved in cancer microenvironment remodeling via activation of Ca2+-triggered signaling. Mechanistically, CamK-A activates Ca2+/calmodulin-dependent kinase PNCK, which in turn phosphorylates I kappa B alpha and triggers calcium-dependent nuclear factor KB (NF-kappa B) activation. This regulation results in the tumor microenvironment remodeling, including macrophage recruitment, angiogenesis, and tumor progression. Notably, our human-patient-derived xenograft (PDX) model studies demonstrate that targeting CamK-A robustly impaired cancer development. Clinically, CamK-A expression coordinates with the activation of CaMK-NF-kappa B axis, and its high expression indicates poor patient survival rate, suggesting its role as a potential biomarker and therapeutic target.
WOS关键词KAPPA-B PATHWAY ; CELL-TRANSFORMATION ; GLUCOSE-METABOLISM ; BREAST-CANCER ; INCRNA ; HIPPO ; RESISTANCE
资助项目National Natural Science Foundation of China[91740205] ; National Natural Science Foundation of China[81672791] ; National Natural Science Foundation of China[81872300] ; National Natural Science Foundation of China[81602137] ; National Natural Science Foundation of China[31571299] ; National Natural Science Foundation of China[31771398] ; Stem Cell and Translational Research ; National Key Research and Development Program of China[2016YFA0101001] ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China[LR18C060002]
WOS研究方向Biochemistry & Molecular Biology ; Cell Biology
语种英语
出版者CELL PRESS
WOS记录号WOS:000446317300009
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Stem Cell and Translational Research ; Stem Cell and Translational Research ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China ; Zhejiang Provincial Natural Science Fund for Distinguished Young Scholars of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166934]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Lin, Aifu
作者单位1.Duke Univ, Sch Med, Div Surg Sci, Dept Surg, Durham, NC 27710 USA
2.Zhejiang Univ, Coll Life Sci, Hangzhou 310058, Zhejiang, Peoples R China
3.Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Collaborat Innovat Ctr Canc Med, Guangzhou 510060, Guangdong, Peoples R China
4.Zhejiang Univ, Sch Med, Dept Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
5.Zhejiang Univ, Sch Med, Program Mol Cell Biol, Hangzhou 310058, Zhejiang, Peoples R China
6.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
7.Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA
8.Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr Translat Canc Res, Houston, TX 77030 USA
9.Key Lab Cell & Gene Engn Zhejiang Prov, Hangzhou 310058, Zhejiang, Peoples R China
10.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Ju, Huai-qiang,Sang, Ling-jie,Liu, Guang-ping,et al. LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling[J]. MOLECULAR CELL,2018,72(1):71-+.
APA Ju, Huai-qiang.,Sang, Ling-jie.,Liu, Guang-ping.,Tian, Tian.,Ma, Guo-lin.,...&Lin, Aifu.(2018).LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling.MOLECULAR CELL,72(1),71-+.
MLA Ju, Huai-qiang,et al."LncRNA CamK-A Regulates Ca2+-Signaling-Mediated Tumor Microenvironment Remodeling".MOLECULAR CELL 72.1(2018):71-+.

入库方式： OAI收割

来源：大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。