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Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration

文献类型：期刊论文

作者Han, Tiegang6; Chen, Kuangcai2; Chen, Jin3,5; Tang, Yan1,4; Wang, Fangjun3; Fang, Ning2; El-Sayed, Mostafa A.6; Wu, Yue6; Ali, Moustafa R. K.6; Dong, Bin2
刊名ACS NANO
出版日期2018-09-01
卷号12期号:9页码:9279-9290
ISSN号1936-0851
关键词collective cancer cell migration metastasis gold nanorods plasmonic photothermal therapy phosphoproteomics STORM super-resolution microscopy
DOI10.1021/acsnano.8b04128
通讯作者Fang, Ning(nfang@gsu.edu) ; Wang, Fangjun(wangfj@dicp.ac.cn) ; El-Sayed, Mostafa A.(melsayed@gatech.edu)
英文摘要Most cancer-related deaths come from metastasis. It was recently discovered that nanoparticles could inhibit cancer cell migration. Whereas most researchers focus on single-cell migration, the effect of nanoparticle treatment on collective cell migration has not been explored. Collective migration occurs commonly in many types of cancer metastasis, where a group of cancer cells move together, which requires the contractility of the cytoskeleton filaments and the connection of neighboring cells by the cell junction proteins. Here, we demonstrate that gold nanorods (AuNRs) and the introduction of near-infrared light could inhibit the cancer cell collective migration by altering the actin filaments and cell junctions with significantly triggered phosphorylation changes of essential proteins, using mass spectrometry-based phosphoproteomics. Further observation using super-resolution stochastic optical reconstruction microscopy (STORM) showed the actin cytoskeleton filament bundles were disturbed, which is difficult to differentiate under a normal fluorescence microscope. The decreased expression level of N-cadherin junctions and morphological changes of tight junction protein zonula occludens 2 were also observed. All of these results indicate possible functions of the AuNR treatments in regulating and remodeling the actin filaments and cell junction proteins, which contribute to decreasing cancer cell collective migration.
WOS关键词TIGHT JUNCTIONS ; BREAST-CANCER ; N-CADHERIN ; QUANTITATIVE PROTEOMICS ; MECHANICAL-PROPERTIES ; ALPHA-CATENIN ; IN-VITRO ; ADHESION ; CYTOSKELETON ; NANOPARTICLES
资助项目National Science Foundation Division of Chemistry (CHE)[1608801] ; National Natural Science Foundation of China[21675152] ; Youth Innovation Promotion Association CAS[2014164] ; NIH[1R01GM115763]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000445972400046
资助机构National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH ; National Science Foundation Division of Chemistry (CHE) ; National Science Foundation Division of Chemistry (CHE) ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association CAS ; Youth Innovation Promotion Association CAS ; NIH ; NIH
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166990]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Wang, Fangjun; Fang, Ning; El-Sayed, Mostafa A.
作者单位1.Harvard Med Sch, Boston, MA 02115 USA
2.Georgia State Univ, Dept Chem, POB 3965, Atlanta, GA 30302 USA
3.Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Liaoning, Peoples R China
4.Brigham & Womens Hosp, Dept Med Pulm & Crit Care Med, Boston, MA 02115 USA
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Sch Chem & Biochem, Georgia Inst Technol, Laser Dynam Lab, Atlanta, GA 30332 USA
推荐引用方式
GB/T 7714		 Han, Tiegang,Chen, Kuangcai,Chen, Jin,et al. Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration[J]. ACS NANO,2018,12(9):9279-9290.
APA Han, Tiegang.,Chen, Kuangcai.,Chen, Jin.,Tang, Yan.,Wang, Fangjun.,...&Dong, Bin.(2018).Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration.ACS NANO,12(9),9279-9290.
MLA Han, Tiegang,et al."Gold Nanorod Photothermal Therapy Alters Cell Junctions and Actin Network in Inhibiting Cancer Cell Collective Migration".ACS NANO 12.9(2018):9279-9290.

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来源：大连化学物理研究所

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