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Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation

文献类型：期刊论文

作者Wang, Shutao1,2; Chen, Cheng1,3; Liang, Xinmiao3; Song, Yongyang1,2; Li, Xiuling3; Fan, Jun-Bing2; Kang, Hongjian1,3; Zhang, Xiaofei3
刊名ADVANCED MATERIALS
出版日期2018-09-26
卷号30期号:39页码:8
关键词emulsion interfacial polymerization glycopeptide separation heterostructured nanopores porous particles
ISSN号0935-9648
DOI10.1002/adma.201803299
通讯作者Liang, Xinmiao(liangxm@dicp.ac.cn) ; Wang, Shutao(stwang@mail.ipc.ac.cn)
英文摘要Porous polymer materials are extensively used for biomolecule separation. However, conventional homogeneous porous polymer materials cannot efficiently separate specific low-abundance biomolecules from complex samples. Here, particles fabricated by emulsion interfacial polymerization featuring heterostructured nanopores with tunable size are reported, which can be used to realize low-abundance glycopeptide (GP) separation from complex biofluids. The heterostructured surface inside the nanopores allows solvent-dependent local adsorption of biomolecules onto hydrophilic or hydrophobic regions. Low-abundance hydrophilic GPs in complex biofluids can be efficiently separated via the hydrophilic region of nanopores in low-polarity solvent after the hydrophobic region removes high-abundance hydrophobic proteins and non-glycopeptides in high-polarity solvent. It is expected that these particles with heterostructured nanopores can be used for separation of nucleic acids, saccharides, and proteins, and downstream clinical diagnosis.
WOS关键词ALZHEIMERS-DISEASE ; MESOPOROUS SILICA ; MASS-SPECTROMETRY ; BETA-PEPTIDE ; PLASMID DNA ; CHROMATOGRAPHY ; PROTEIN ; EXTRACTION ; ENRICHMENT ; PURIFICATION
资助项目National Natural Science Foundation of China[21425314] ; National Natural Science Foundation of China[21775148] ; National Natural Science Foundation of China[21504098] ; National Natural Science Foundation of China[51533007] ; National Natural Science Foundation of China[21434009] ; National Natural Science Foundation of China[21475129] ; Key Research Program of the Chinese Academy of Sciences[KJZD-EW-M01] ; MOST[2013YQ190467] ; Beijing Municipal Science & Technology Commission[Z161100000116037] ; Top-Notch Young Talents Program of China
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
WOS记录号WOS:000445327500022
出版者WILEY-V C H VERLAG GMBH
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; MOST ; MOST ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Top-Notch Young Talents Program of China ; Top-Notch Young Talents Program of China
源URL[http://cas-ir.dicp.ac.cn/handle/321008/166994]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Wang, Shutao; Liang, Xinmiao
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Bioinspired Mat & Interfacial Sci, CAS Ctr Excellence Nanosci Tech Inst Phys & Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Shutao,Chen, Cheng,Liang, Xinmiao,et al. Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation[J]. ADVANCED MATERIALS,2018,30(39):8.
APA Wang, Shutao.,Chen, Cheng.,Liang, Xinmiao.,Song, Yongyang.,Li, Xiuling.,...&Zhang, Xiaofei.(2018).Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation.ADVANCED MATERIALS,30(39),8.
MLA Wang, Shutao,et al."Interfacially Polymerized Particles with Heterostructured Nanopores for Glycopeptide Separation".ADVANCED MATERIALS 30.39(2018):8.

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来源：大连化学物理研究所

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