中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 大连化学物理研究所
  3. 中国科学院大连化学物理研究所
Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection

文献类型：期刊论文

作者Wang, Li1; Qin, Jianhua1,2,3; Zhu, Yujuan1,2,4; Yin, Fangchao1,2; Wang, Hui1,2; Yuan, Jingli4
刊名ACS BIOMATERIALS SCIENCE & ENGINEERING
出版日期2018-09-01
卷号4期号:9页码:3356-3363
关键词placental barrier-on-a-chip placental inflammation bacterial infection organ-on-a-chip
ISSN号2373-9878
DOI10.1021/acsbiomaterials.8b00653
通讯作者Qin, Jianhua(jhqin@dicp.ac.cn)
英文摘要Placental inflammation, as a recognized cause of preterm birth and neonatal mortality, displays extensive placental involvement or damage with the presence of organisms. The inflammatory processes are complicated and tightly associated with increased inflammatory cytokine levels and innate immune activation. However, the deep study of the underlying mechanisms was limited by conventional cell and animal models because of great variations in the architecture and function of placenta. Here, we established a micro engineered model of human placental barrier on the chip and investigated the associated inflammatory responses to bacterial infection. The multilayered design of the microdevice mimicked the microscopic structure in the fetal-maternal interfaces of human placenta, and the flow resembled the dynamic environment in the mother's body. Escherichia coli (E. coli), one of the predominant organisms found in fetal organs, were applied to the maternal side, modeling acute placental inflammation. The data demonstrated the complex responses including the increased secretion of inflammatory cytokines by trophoblasts and the adhesion of maternal macrophages following bacterial infection. Particularly, transplacental communication was observed between two placental cells, and implied the potential role of trophoblast in fetal inflammatory response syndrome in clinic. These complex responses are of potential significance to placental dysfunctions, even abnormal fetal development and preterm birth. Collectively, placental barrier-on-a-chip microdevice presents a simple platform to explore the complicated inflammatory responses in human placenta, and might help our understanding of the mechanisms underlying reproductive diseases.
WOS关键词ENDOTHELIAL-CELLS ; PRETERM BIRTH ; IN-VITRO ; TROPHOBLAST ; PREGNANCY ; CHORIOAMNIONITIS ; PREECLAMPSIA ; MICROBIOME ; JUNCTIONS ; GROWTH
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB0305] ; Key Program of the Chinese Academy of Sciences[KFZD-SW-213] ; National Key R&D Program of China[2017YFB0405400] ; National Nature Science Foundation of China[91543121] ; National Nature Science Foundation of China[81573394] ; National Nature Science Foundation of China[31671038] ; Innovation Program of Science and Research from the DICP, CAS[DICP TMSR201601]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000444526900022
出版者AMER CHEMICAL SOC
资助机构Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; Key Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; National Key R&D Program of China ; National Nature Science Foundation of China ; National Nature Science Foundation of China ; Innovation Program of Science and Research from the DICP, CAS ; Innovation Program of Science and Research from the DICP, CAS
源URL[http://cas-ir.dicp.ac.cn/handle/321008/167006]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者Qin, Jianhua
作者单位1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Div Biotechnol, Dalian 116023, Peoples R China
2.Chinese Acad Sci, Inst Stem Cell & Regenerat, Beijing 100864, Peoples R China
3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China
4.Dalian Univ Technol, Coll Chem, Dalian 116024, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Li,Qin, Jianhua,Zhu, Yujuan,et al. Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(9):3356-3363.
APA Wang, Li,Qin, Jianhua,Zhu, Yujuan,Yin, Fangchao,Wang, Hui,&Yuan, Jingli.(2018).Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(9),3356-3363.
MLA Wang, Li,et al."Placental Barrier-on-a-Chip: Modeling Placental Inflammatory Responses to Bacterial Infection".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.9(2018):3356-3363.

入库方式： OAI收割

来源：大连化学物理研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。